DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b1 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	549	Identity:	135/549 - (24%)
Similarity:	216/549 - (39%)	Gaps:	108/549 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ICLVLATIGLL---LFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQ---KASFQKQI----S 60
            ||....|..||   |.||.  ..|...|    ....:||:||    |||   ...|..|:    :
Zfish    20 ICFAYITYQLLKSYLHKWK--ELKPIPG----IGNTFPFIGN----ALQFKSNGDFFLQLVGYTT 74

  Fly    61 EFYNRTRHHKLVG------LFNLRTPMIQINDPQLIKKICVKDFDHFPNHQTLNIPNERLVNDML 119
            ||.|.......:|      ||:..|....:|:|..|.|.....|.|           ..|...:|
Zfish    75 EFQNSPLLKIWIGPIPFLILFHAETVETVLNNPVHIDKAYAYQFLH-----------PWLGTGLL 128

  Fly   120 NVMRDQHWRNMRSVLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKV-LCN 183
            ....|: ||..|.:|||.|..:.:.....:|||.....:|.|:..    ||:..|.....: ||
Zfish   129 TSTGDK-WRRRRKMLTPTFHFSILTEFLEVMNEQAEVLIEKLEKQ----AGKGPFNCFSHITLC- 187

  Fly   184 KLSNDVIATTAFGLKV---NSFDD-----------------------PENEFHTIGKTLAFSRGL 222
              :.|:|..||.|.::   :::|.                       |:..::.:|:....:|.|
Zfish   188 --ALDIICETAMGKRIYAQSNYDSEYVRTVYRMSDIITRRQRMPWYWPDFVYNYVGEGREHNRSL 250

  Fly   223 PFLKFMMCLLAPKVFNFFKLTIFDSTNVEY--FVRLVVDAMQYREKHNITRPDMIQLLMEAKKES 285
                        |:.:.|..::.:. ..||  :|....::.|...|    |...:.:|::.|.|.
Zfish   251 ------------KILHSFTESVINE-RAEYLSYVESDSESDQGMRK----RRAFLDMLLKTKDED 298

  Fly   286 KDNWTDDEIVAQCFIFFFAAFENNSNLICTTAYELLRNLDI----QERLYEEVKETQEALKGAPL 346
            ....|..:|..:...|.|...:..:..:....:.|..:.::    |:.|:|...|::.     |:
Zfish   299 GKMLTHKDIQEEVDTFMFEGHDTTAAAMNWAIHLLGSHPEVQRKAQQELFEVFGESER-----PV 358

  Fly   347 TYDAAQEMTYMDMVISESLRKWTLSAAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWD 411
            ..:..:::.|::.||.||||.:.......|      |:.||.....|:...|.||.:....||.|
Zfish   359 NTEDLKKLRYLECVIKESLRLFPSVPFFAR------TICDDTQINGFKVPKGTNIVVITYALHRD 417

  Fly   412 ERFFPQPQRFDPERFSERRKKDLIPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASP 476
            .||||.|:.|.||||.........||.|:||..|.|:|||.|:|:|:.|.:|..::..:.|.|..
Zfish   418 PRFFPDPEEFRPERFLPENCVGRHPYAYIPFSAGLRNCIGQRFAIMEEKVILAYILRYFNIVACQ 482

  Fly   477 RTTRDMWESARGFNIIPTTGFWMQLVSRK 505
            :  |:.........:.|..|.|:.|..||
Zfish   483 K--REELRPLGELVLRPEQGIWITLERRK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	118/486 (24%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	121/513 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900