DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b1 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	541	Identity:	145/541 - (26%)
Similarity:	249/541 - (46%)	Gaps:	83/541 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYNRTRHH 69
            |...:||.:..||..:.:...:.|:...:...|..||.|.|.........|.....|.|.|
Zfish     6 ETWTLLAFLAALLVIYGSWPHRYFKKLGIPGPKAIPFFGTMLRYKDGFHVFDMDCFEKYGR---- 66

  Fly    70 KLVGLFNLRTPMIQINDPQLIKKICVKD-FDHFPNHQTLNIPNERL---VNDMLNVMRDQHWRNM 130
             :.|:::.|.|::.|.|..:||.:.:|: :..|.|.:     |.||   :.|.:::..|..||.:
Zfish    67 -IWGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRR-----NFRLNGALYDAVSIAEDDDWRRI 125

  Fly   131 RSVLTPVFTSAKMRNMFTLMNESFAQCLEHL---KSSQPIAAGENAFELDMKVLCNKLSNDVIAT 192
            ||||:|.|||.:::.||.:|.:.     .|:   ...:....||:|   |:|......|.||:.:
Zfish   126 RSVLSPSFTSGRLKEMFGIMKKH-----SHILVDSMGKTAKRGESA---DIKEFFGAYSMDVVTS 182

  Fly   193 TAFGLKVNSFDDPENEFHT-IGKTLAFSRGLP------FLKFMMCLLAPKVFNFFKLTIFDSTNV 250
            |||.:.::|.::|::.|.| |.|.|.|....|      |..||..:|....|..|..::.|
Zfish   183 TAFSVDIDSLNNPKDPFVTNIKKMLKFDLLNPLFLLIAFFPFMAPVLEKMDFALFPTSVTD---- 243

  Fly   251 EYFVRLVVDAMQYREKHNIT------RPDMIQLLMEAK---------KESKDNWTDDEIVAQCFI 300
             :|...:......|:...:.      |.|.:||:::::         :.::...:|.||::|..|
Zfish   244 -FFYAALQKIKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDGEHTEKGLSDHEILSQSMI 307

  Fly   301 FFFAAFENNSNLICTTAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAAQEMTYMDMVISESL 365
            |.||.:|.:|:.:....|.|..|.:..::|.||:.||..  ..||:.|:....|.|:|..:||||
Zfish   308 FIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFP--NQAPVDYETLMSMDYLDAALSESL 370

  Fly   366 RKWTLSAAADRLCAKDYTLTDDEGTKLFEFKAGDN---------INIPICGLHWDERFFPQPQRF 421
            |.:.::|..:|:|.|...:               |         :.:|...||.|..::.:|:.|
Zfish   371 RLFPVAARLERVCKKTVEI---------------NGLLIPKDLVVMVPTYALHRDPDYWSEPESF 420

  Fly   422 DPERFSERRKKDLIPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRTTRDMWESA 486
            .||||::..|:.:.||.|:|||:|||:|||.|:|.:..|..:..::..:.:.....|...:   .
Zfish   421 KPERFTKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQVPL---E 482

  Fly   487 RGFN--IIPTTGFWMQLVSRK 505
            .|||  :.|.....::|..||
Zfish   483 LGFNGLLSPKDPIKLKLQPRK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	131/478 (27%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	136/506 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3329
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.870