DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b1 and Cyp3a41a

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_059092.2	Gene:	Cyp3a41a / 53973	MGIID:	1858451	Length:	504	Species:	Mus musculus

Alignment Length:	515	Identity:	163/515 - (31%)
Similarity:	263/515 - (51%)	Gaps:	48/515 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYNRTRHHKLV 72
            ::||.|.:||:::.|.|...|:.:.:...||.||||.:.........|..:..|.|.:|     .
Mouse    13 VLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYKGLWKFDMECYEKYGKT-----W 72

  Fly    73 GLFNLRTPMIQINDPQLIKKICVKD-FDHFPNHQTLNIPNERLVNDMLNVMRDQHWRNMRSVLTP 136
            |||:.:.|:..|.||::||.:.||: |..|.|.:......  :::..:::.:|:.|:..|::|:|
Mouse    73 GLFDGQMPLFVITDPEMIKNVLVKECFSVFTNRREFGPVG--IMSKAISISKDEEWKRYRALLSP 135

  Fly   137 VFTSAKMRNMFTLMNESFAQCL-----EHLKSSQPIAAGENAFELDMKVLCNKLSNDVIATTAFG 196
            .|||.|::.||.:: |.:...|     :..:..:|:.         ||.:....|.|||.:|:||
Mouse   136 TFTSGKLKEMFPVI-EQYGDILVKYLMQEAEKGKPVT---------MKDVLGAYSIDVITSTSFG 190

  Fly   197 LKVNSFDDPENEFHTIGKTLA---FSRGLPFLKFMMCLLAPKVFNFFKLTIFDSTNVEYFVRLV- 257
            :.|:|.::||:.|....|.:.   |...|.|...:...|.| |:....:.:|...::|:|.:.|
Mouse   191 VNVDSLNNPEDPFVEKAKGILRVDFFDPLVFSVVLFPFLTP-VYEMLNICMFPKDSIEFFKKFVN 254

  Fly   258 ---VDAMQYREKHNITRPDMIQLLMEAKKESKDN-----WTDDEIVAQCFIFFFAAFENNSNLIC 314
               ...:..::||   |.|.:||:|.|...|||.     .:|.||.||..:|.||.:|..|:.:.
Mouse   255 RMKESRLDSKQKH---RVDFLQLMMNAHNNSKDKDSHKALSDMEITAQSIVFIFAGYETTSSTLS 316

  Fly   315 TTAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAAQEMTYMDMVISESLRKWTLSAAADRLCA 379
            .|.|.|..:.|||::|.||:.||..  ..||.|||...||.|:|||::|:||.:.:....:|.|.
Mouse   317 FTLYCLATHPDIQKKLQEEIDETLP--NKAPPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCK 379

  Fly   380 KDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLIPYTYLPFGV 444
            ||..|   .|..:   ..|..:.||...||.|.:.:|:|:.|.|||||:..|..:.||.|:|||:
Mouse   380 KDVEL---NGVYI---PKGSTVMIPSYALHHDPQHWPEPEEFQPERFSKENKGSIDPYLYMPFGI 438

  Fly   445 GPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRTTRDMWESARGFNIIPTTGFWMQLVSR 504
            |||:|||.|:|.|..|..|..:|.|:..:....|...:..|.:|. :.|.....:::|.|
Mouse   439 GPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQIPLKLSRQGL-LQPEKPIVLKVVPR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	149/458 (33%)
Cyp3a41a	NP_059092.2	p450	39..494	CDD:278495	153/484 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.770