DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b1 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	498	Identity:	134/498 - (26%)
Similarity:	244/498 - (48%)	Gaps:	61/498 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LVLATIGLLLF--KWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYNRTRHHK 70
            ||...|.||..  .|..|.||..   .:...:|:||.|...:......:|..:.::.|.     |
Zfish    13 LVFLVITLLYMYGVWPHGFFKKL---GIPGPRPWPFFGTFLSYTKGFFNFDMECAKKYG-----K 69

  Fly    71 LVGLFNLRTPMIQINDPQLIKKICVKD-FDHFPNHQTLNIPNERLVNDMLNVMRDQHWRNMRSVL 134
            :.|:::.|.|::.:.|.::||.|.||: :..|.|.:.:|:.....:.|.::.::|:.|:.:|..|
Zfish    70 VWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREVNVDLAGPLADGISAVKDERWKRIRGTL 134

  Fly   135 TPVFTSAKMRNMFTLM---NESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVIATTAFG 196
            :|.|||.:::.:|.:.   .:.|.:.::.....||:         .:|.:....|.||:.:::|.
Zfish   135 SPYFTSGRLKEIFPIAMTHADRFIKNMQKRDHEQPV---------KIKEVVAPYSLDVVTSSSFS 190

  Fly   197 LKVNSFDDPENEFHT-IGKTLAFSRGLPFLKFMMCLLAPKVFNF---FKLTIFDSTNVEYF---V 254
            :.::|.::|::.|.| |...|.||...|.:.|:  .|.|.:.|.   ..:::|..:.:.:|   :
Zfish   191 VDIDSINNPDDPFVTNIKNFLKFSLFSPLILFL--TLFPSIANLLGKMGISVFSRSIMNFFYTAL 253

  Fly   255 RLVVDAMQYREKHNITRPDMIQLLMEAK---KESKD--------NWTDDEIVAQCFIFFFAAFEN 308
            |.:.|    ..|.:..|.|.::|:::.:   .::||        ..||.||::|.|||....:|.
Zfish   254 RKIKD----EHKDSNGRVDFLRLMIQNQIPDDQAKDTTSEQPVKGLTDHEILSQSFIFILGGYET 314

  Fly   309 NSNLICTTAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAAQEMTYMDMVISESLRKWTLSAA 373
            .|..:....:.|..|.|..|:|.||:.:....  ..|::|||..:|.|::|.|:||:|....:..
Zfish   315 TSTTLSFLLHNLATNPDCLEKLVEEIDKNFPL--DTPISYDALMKMDYLEMSINESMRLLPTAPR 377

  Fly   374 ADRLCAKDYTL---TDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLI 435
            .:|:|.|...|   |..:.|.         :.||...|:.|.:.:..||.|.|||||...|.:.:
Zfish   378 LERVCKKTVELNGITIPKDTL---------VAIPTYVLNRDPQLWDSPQEFRPERFSPENKSEFL 433

  Fly   436 PYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRT 478
            .|.::|||:|||:|||.|:|:|..|.::..|:.|:.:|....|
Zfish   434 QYAFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKET 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	124/465 (27%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	125/470 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3329
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.770