DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9b1 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	165/509 - (32%)
Similarity:	260/509 - (51%)	Gaps:	38/509 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ICLVLATIGLLLF---KWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQIS-EFYNRT 66
            :.:::.|:||||:   :|.   :..:..|.:..|:|..|.|||  |.|.:......|: ..|.:.
  Fly     4 LLVLVFTVGLLLYVKLRWH---YSYWSRRGVAGERPVYFRGNM--SGLGRDLHWTDINLRIYRKF 63

  Fly    67 RH-HKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNHQTL-NIPNERLVNDMLNVMRDQHWRN 129
            |. .:..|.|...|..:.|.|.:||:.|.::||..|.:.... |:.::.|..::| .:....||.
  Fly    64 RGVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNLL-FLDGPEWRW 127

  Fly   130 MRSVLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVIATTA 194
            :|..||.||||.||:.||..|    .:..|.|..:..:..|    |::.|.||.:.:.|||.:.|
  Fly   128 LRQNLTQVFTSGKMKFMFPNM----VEVGEKLTQACRLQVG----EIEAKDLCARFTTDVIGSCA 184

  Fly   195 FGLKVNSFDDPENEFHTIGKTLAFSRGLPFLKFMMCLLAPKVFNFFKLTIFDSTNVEYFVRLVVD 259
            |||:.||..|||::|..:|:::........|........|::....:..:|.....|:|:..|..
  Fly   185 FGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTVRQ 249

  Fly   260 AMQYREKHNITRPDMIQLLMEAKKES-KDNWTDDEIVAQCFIFFFAAFENNSNLICTTAYELLRN 323
            .:.||.:.||.|.|:||||||..:|. ||..:.::|.||..:||.|.|:.:|..:....|||..|
  Fly   250 TLDYRRRENIHRNDLIQLLMELGEEGVKDALSFEQIAAQALVFFLAGFDTSSTTMSFCLYELALN 314

  Fly   324 LDIQERLYEEV-----KETQEALKGAPLTYDAAQEMTYMDMVISESLRKWTLSAAADRLCAKDYT 383
            .|:||||..||     :..|:      ||||:.|||.|:|.|::|:|||:.:.....|...|:|.
  Fly   315 PDVQERLRVEVLAVLKRNNQK------LTYDSVQEMPYLDQVVAETLRKYPILPHLLRRSTKEYQ 373

  Fly   384 LTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLIPYTYLPFGVGPRS 448
            :.:..    ...:.|..|.||:..:|.|...:|.|::|||.||.....|...|:.|||||.|||:
  Fly   374 IPNSN----LILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGEGPRN 434

  Fly   449 CIGNRYAVMQAK-GMLYNLMLNYKIEASPRTTRDMWESARGFNIIPTTGFWMQL 501
            |||.|:..:|.| |::| |:.::|...|.:|...:..|:|.|.|....|..:::
  Fly   435 CIGERFGKLQVKVGLVY-LLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRM 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	151/450 (34%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	155/464 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461276
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800