DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9b1 and Cyp6w1

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	505	Identity:	146/505 - (28%)
Similarity:	263/505 - (52%)	Gaps:	49/505 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYNRT--RH 68
            :.|:|.::.::.:.|...|...:|...:.:.:|:|.:|........|..|.:||.:|:...  .:
  Fly     3 LLLLLGSLTIVFYIWQRRTLSFWERHGVKYIRPFPVVGCTREFLTAKVPFFEQIQKFHEAPGFEN 67

  Fly    69 HKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNHQTLNIP-NERLVNDMLNVMRDQHWRNMRS 132
            ...||::....|.:.|.|.:|||.:.:|.|.:|.|......| |:.|....|...|...||.:|:
  Fly    68 EPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYKNLFFARSPGWRELRT 132

  Fly   133 VLTPVFTSAKMRNMFTLM---NESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVIATTA 194
            .::|||||.|::.|:.||   .::.....|.|.|..         |:.:|.||::.:.|:|||.|
  Fly   133 KISPVFTSGKIKQMYPLMVKIGKNLQDSAERLGSGT---------EVQVKDLCSRFTTDLIATIA 188

  Fly   195 FGLKVNSFDDPENEFHTIGK---TLAFSRGLPF-LKFMMCLLAPKVFNFFKLTIFDSTNVEYFVR 255
            ||::.|:..|.::||....:   :|..|||:.| :.||:    |.:.:..::.:| |.....|:|
  Fly   189 FGVEANALQDAKSEFFYHNRAIFSLTLSRGIDFAIIFMI----PALASLARVKLF-SRETTKFIR 248

  Fly   256 LVVD-AMQYREKHNITRPDMIQLLMEAKKESKDN------WTD-DEIVAQCFIFFFAAFENNSNL 312
            ..|: .::.||:....|.|:|.:|:..|:|:..|      ..| |.:|||..:|..|.||.:::.
  Fly   249 SSVNYVLKERERTGEKRNDLIDILLALKREAAANPGKMSKEVDLDYLVAQAAVFQTAGFETSAST 313

  Fly   313 ICTTAYELLRNLDIQERLYEEVKE---TQEALKGAPLTYDAAQEMTYMDMVISESLRKWTLSAAA 374
            :..|.|||.:|..:|:||.:|:.:   .::     .::|:..|||.|:..|::|:|||:.:....
  Fly   314 MTMTLYELAKNEALQDRLRQEIVDFFGDED-----HISYERIQEMPYLSQVVNETLRKYPIVGYI 373

  Fly   375 DRLCAKD-----YTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDL 434
            :|.|::.     :||   |.....|...|.:|.:....:|.|.:::|.|:::|||||:...:.:|
  Fly   374 ERECSQPAEGERFTL---EPFHNMELPHGMSIYMSTVAVHRDPQYWPDPEKYDPERFNSSNRDNL 435

  Fly   435 IPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRTTRDM-W 483
            ....|:|||||||:|||.|..::|:|..|.:::.|::.....:|.:.: |
  Fly   436 NMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKKIEW 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	139/466 (30%)
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	141/474 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461062
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800