DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b1 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	517	Identity:	160/517 - (30%)
Similarity:	267/517 - (51%)	Gaps:	44/517 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYNRTRH 68
            ::..::||.|.:||:::.|.|...|:.:.:...||.||||.:.........|..:..|.|.:|
Mouse     9 LDTLVLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYTGIWKFDMECYEKYGKT-- 71

  Fly    69 HKLVGLFNLRTPMIQINDPQLIKKICVKD-FDHFPNHQTLNIPNERLVNDMLNVMRDQHWRNMRS 132
               .|||:.:||::.|.||:.||.:.||| ...|.|.:......  :::..:::.:|:.|:..|:
Mouse    72 ---WGLFDGQTPLLVITDPETIKNVLVKDCLSVFTNRREFGPVG--IMSKAISISKDEEWKRYRA 131

  Fly   133 VLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVIATTAFGL 197
            :|:|.|||.:::.||.::.:.....:::|:..     .|....:.||.:....|.|||.:|:||:
Mouse   132 LLSPTFTSGRLKEMFPVIEQYGDILVKYLRQE-----AEKGMPVAMKDVLGAYSMDVITSTSFGV 191

  Fly   198 KVNSFDDPENEFHTIGK---TLAFSRGLPFLKFMMCLLAPKVFNFFKLTIFDSTNVEYFVRLVVD 259
            .|:|.::||:.|....|   .:.|...|.|...:..||.| |:....:.:|.:.::|:|.:. ||
Mouse   192 NVDSLNNPEDPFVEEAKKFLRVDFFDPLLFSVVLFPLLTP-VYEMLNICMFPNDSIEFFKKF-VD 254

  Fly   260 AMQ-----YREKHNITRPDMIQLLMEAKKESKDN-----WTDDEIVAQCFIFFFAAFENNSNLIC 314
            .||     ..:||   |.|.:||:|.:...|||.     :::.||..|..||..|.:|..|:.:.
Mouse   255 RMQESRLDSNQKH---RVDFLQLMMNSHNNSKDKDSHKAFSNMEITVQSIIFISAGYETTSSTLS 316

  Fly   315 TTAYELLRNLDIQERLYEEVKETQEAL--KGAPLTYDAAQEMTYMDMVISESLRKWTLSAAADRL 377
            .|.|.|..:.|||::|..|:   .:||  |..| |.|...||.|:|||::|:||.:.:....:|:
Mouse   317 FTLYCLATHPDIQKKLQAEI---DKALPNKATP-TCDTVMEMEYLDMVLNETLRLYPIVTRLERV 377

  Fly   378 CAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLIPYTYLPF 442
            |.||..|   .|..:   ..|..:.||...||.|.:.:|.|:.|.|||||:..|..:.||.||||
Mouse   378 CKKDVEL---NGVYI---PKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKENKGSIDPYVYLPF 436

  Fly   443 GVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRTTRDMWESARGFNIIPTTGFWMQLVSR 504
            |:|||:|||.|:|:|..|..:..::.|:..:....|...:..|.:|. :.|.....:::|.|
Mouse   437 GIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQGI-LQPEKPIVLKVVPR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	146/456 (32%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	150/482 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.770