DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9b1 and Cyp309a1

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	489	Identity:	116/489 - (23%)
Similarity:	215/489 - (43%)	Gaps:	32/489 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SFVEICLVLATIGL-LLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKA-SFQKQISEFYN 64
            :.|.:||.:..:.. :::.:.|...|.::.|.:...:|...||:.....:.|: |....:.:.||
  Fly     3 TLVGLCLTIVHVAFAVVYFYLTWYHKYWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYN 67

  Fly    65 RTR-HHKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNHQTLNI----PNERLVNDMLNVMRD 124
            :.: .::.||.|..|.|.:.:.||.|..:|.|..|.||.:..|.:.    |:::.|.........
  Fly    68 KYKDKYRTVGTFITRQPQLLVLDPALAHEILVDKFSHFRDTITSSFVGHNPDDKYVAGSPFFSAG 132

  Fly   125 QHWRNMRSVLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDV 189
            ..|:.:||......|.::::..:::..:|..:.:|:::.    |..|....::.:.|..:.:.:.
  Fly   133 DKWKRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIER----ARREQGDIIETRDLAYRFTANA 193

  Fly   190 IATTAFGLKVNSFDDPENEFHTIGKTL------AFSRGLPFLKFMMCLLAPKVFNFFKLTIFDST 248
            :|...:|:...|......|.....||.      |||..:.|.|.::.:...|:|:   :..|...
  Fly   194 MADFIWGIDAGSLSGKVGEIGDFQKTSTDWSAHAFSSMIRFNKTLVAIFVRKLFS---MRFFTKA 255

  Fly   249 NVEYFVRLVVDAMQYRE-KHNITRPDMIQLLMEAKKESKDNWTDDEIVAQCFIFFFAAFENNSNL 312
            ..|:|:||..||:..|: .....|.|.:..|::.  :.:.|...|. |..........||.:..:
  Fly   256 TDEFFLRLTQDAVNLRQGGSGEGRTDYLSHLIQL--QQRGNSIHDS-VGHALTVHLDGFETSGAV 317

  Fly   313 ICTTAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAAQEMTYMDMVISESLRKWTLSAAADRL 377
            :....|.|..:.:.||:|..|:.|.. |.:| .::||....:.|:|...:||||..|......|:
  Fly   318 LYHMLYSLSEHHEEQEKLRSEILEAL-ASEG-QISYDQINNLPYLDQCFNESLRLTTPIGFFMRI 380

  Fly   378 CAK--DYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLIPY-TY 439
            |.|  ...|.||   |..:.:.|..:.:|....|.|...:|:...|.|:||.......|... .:
  Fly   381 CTKPTQINLGDD---KTLDLEPGVTVMVPAYQYHHDNDIYPEASEFRPDRFENGAASVLTKRGCF 442

  Fly   440 LPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIE 473
            ||||.|||.|:|.|...:..|..:.:::.||::|
  Fly   443 LPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVE 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	110/453 (24%)
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	107/443 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460912
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.000