DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b1 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_796281.1	Gene:	Cyp4f39 / 320997	MGIID:	2445210	Length:	532	Species:	Mus musculus

Alignment Length:	548	Identity:	113/548 - (20%)
Similarity:	204/548 - (37%)	Gaps:	104/548 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ICLVLATIGLLLFKWSTGTFKAFEGRNLYFEK----PYP-----FLGNMAASALQKASFQ--KQI 59
            :..:|..:....|:.....||.|....:...|    |.|     .||:|:.....:...|  |::
Mouse    24 VSALLLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRHWLLGHMSMYLPNEKGLQNEKKV 88

  Fly    60 SEFYNRTRHHKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNHQTLNIPNERLVNDMLNVMRD 124
            .:    |.||.::.......|::.:..|..||.:........|..:......:..:.|.|.:.:.
Mouse    89 LD----TMHHIILAWVGPFLPLLVLVHPDYIKPVLGASAAIAPKDEFFYSFLKPWLGDGLLISKG 149

  Fly   125 QHWRNMRSVLTPVFTSAKMRNMFTLMNESFAQC--LEHLKSSQPIAAGENAFELDMKVLCNKLSN 187
            ..|...|.:|||.|....::....:.|    ||  :.|.|..:.:|.| :....||....:.::.
Mouse   150 NKWSRHRRLLTPAFHFDILKPYMKIFN----QCTNIMHAKWRRHLAEG-SVTSFDMFEHISLMTL 209

  Fly   188 DVIATTAFGLKVNSFDDPENEFHTIGKTLAFSRGLPFLKFMMCLLAPKVFNFFKLTIFDSTNVEY 252
            |.:....|     |::....|           |...::..::.|.|..|...::|..:    :::
Mouse   210 DSLQKCVF-----SYNSDCQE-----------RMSDYISSIIELSALVVRRQYRLHHY----LDF 254

  Fly   253 FVRLVVDAMQYREK----HNITRP--------------------------DMIQLLMEAKKESKD 287
            ...|..|..::|:.    ||.|..                          |.|.:|:.||.|...
Mouse   255 MYYLTADGRRFRQACDTVHNFTTEVIQERRQALRQQGAEAWLKAKQGKTLDFIDVLLLAKDEEGK 319

  Fly   288 NWTDDEIVAQCFIFFFAAFENNSNLICTTAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAAQ 352
            ..:|::|.|:...|.|...:..|:.:....:.|.:..:.||:..||::|..:..:...|.:|...
Mouse   320 ELSDEDIRAEADTFMFEGHDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGRELEELDWDDLT 384

  Fly   353 EMTYMDMVISESLRKWTLSAAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLH-----WDE 412
            ::.:..|.|.||||::.......|.|.:|..|.|..     ....|....:.|.|.|     |.:
Mouse   385 QLPFTTMCIKESLRQFPPVTLISRRCTEDIKLPDGR-----VIPKGIICLVSIYGTHHNPIVWPD 444

  Fly   413 RFFPQPQRFDPERFSERRKKDLIPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNY------- 470
            .....|.||||:...:|.     |..::||..|||:|||..:|:.:.:.::...:|.:
Mouse   445 SKVYNPYRFDPDTPQQRS-----PLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRT 504

  Fly   471 -KIEASP----RTTRDMWESARGFNIIP 493
             |:...|    ||...:|     .|:.|
Mouse   505 HKVRRKPELILRTENGLW-----LNVEP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	103/500 (21%)
Cyp4f39	NP_796281.1	p450	60..515	CDD:365848	102/493 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900