DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b1 and Cyp3a2

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_695224.3	Gene:	Cyp3a2 / 266682	RGDID:	708379	Length:	504	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	156/490 - (31%)
Similarity:	256/490 - (52%)	Gaps:	41/490 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEF----YN 64
            :|..::||.|.:||::..|.....|:.:.:...||.||||.:       .::.|.:..|    |.
  Rat     9 LETWVLLAVILVLLYRLGTHRHGIFKKQGIPGPKPLPFLGTV-------LNYYKGLGRFDMECYK 66

  Fly    65 RTRHHKLVGLFNLRTPMIQINDPQLIKKICVKD-FDHFPNHQTLNIPNERLVNDMLNVMRDQHWR 128
              ::.|:.|||:.:||:..|.|.::||.:.||: |..|.|.:......  ::...::|.:|:.|:
  Rat    67 --KYGKIWGLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRRDFGPVG--IMGKAVSVAKDEEWK 127

  Fly   129 NMRSVLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVIATT 193
            ..|::|:|.|||.:::.||.::.:.....:::||..     .|....:.||.:....|.|||.:|
  Rat   128 RYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQE-----AETGKPVTMKKVFGAYSMDVITST 187

  Fly   194 AFGLKVNSFDDPENEF-HTIGKTLAFSRGLP-FLKFMMCLLAPKVFNFFKLTIFDSTNVEYFVRL 256
            :||:.|:|.::|::.| ....|.|.|....| ||..::......::....:.:|...::.:|.:.
  Rat   188 SFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSVVLFPFLTPIYEMLNICMFPKDSIAFFQKF 252

  Fly   257 V--VDAMQYREKHNITRPDMIQLLMEAKKESKDN-----WTDDEIVAQCFIFFFAAFENNSNLIC 314
            |  :...:...||. .|.|.:||::.|...|||.     .:|.||:||..||.||.:|..|:.:.
  Rat   253 VHRIKETRLDSKHK-HRVDFLQLMLNAHNNSKDEVSHKALSDVEIIAQSVIFIFAGYETTSSTLS 316

  Fly   315 TTAYELLRNLDIQERLYEEVKETQEALKG-APLTYDAAQEMTYMDMVISESLRKWTLSAAADRLC 378
            ...|.|..:.|||::|.||:   ..||.. ||.|||...||.|:|||::|:||.:.:....:|:|
  Rat   317 FVLYFLATHPDIQKKLQEEI---DGALPSKAPPTYDIVMEMEYLDMVLNETLRLYPIGNRLERVC 378

  Fly   379 AKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLIPYTYLPFG 443
            .||..|   :|  || ...|..:.||...||.|.:.:|:|:.|.|||||:..|..:.||.|||||
  Rat   379 KKDIEL---DG--LF-IPKGSVVTIPTYALHHDPQHWPKPEEFHPERFSKENKGSIDPYVYLPFG 437

  Fly   444 VGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRT 478
            .|||:|||.|:|:|..|..|..::.|:..:....|
  Rat   438 NGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKET 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	147/455 (32%)
Cyp3a2	NP_695224.3	CYP3A	67..493	CDD:410743	139/423 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1960
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm9060
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870