Protein Alignment Cyp9b1 and CYP3A5

DIOPT Version :9

• Sequence 1: NP_523645.1
• Gene: Cyp9b1 / 35634
• FlyBaseID: FBgn0015038
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 498
• Identity: 151/498 - (30%)
• Similarity: 258/498 - (51%)
• Gaps: 59/498 - (11%)

  Fly     4 VEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYNRTRH 68
            ||..|:||...:||:.:.|.|...|:...:....|.|.|||:.:   .:....|..:|.|.  ::
Human     9 VETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLS---YRQGLWKFDTECYK--KY 68

  Fly    69 HKLVGLFNLRTPMIQINDPQLIKKICVKD-FDHFPNHQTLNIPNERLVNDMLNVMRDQHWRNMRS 132
            .|:.|.:..:.|::.|.||.:|:.:.||: :..|.|.::|....  .:...:::..|:.|:.:||
Human    69 GKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVG--FMKSAISLAEDEEWKRIRS 131

  Fly   133 VLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVIATTAFGL 197
            :|:|.|||.|::.||.::.:.....:.:|:..     .|....:.:|.:....|.|||..|:||:
Human   132 LLSPTFTSGKLKEMFPIIAQYGDVLVRNLRRE-----AEKGKPVTLKDIFGAYSMDVITGTSFGV 191

  Fly   198 KVNSFDDPENEF-HTIGKTLAFSRGLPFLK--FMMCLLAPKVFNFFKLTIFDSTNVEYFV----- 254
            .::|.::|::.| .:..|.|.|.    ||.  |:..:|.|     |...:|::.||..|.
Human   192 NIDSLNNPQDPFVESTKKFLKFG----FLDPLFLSIILFP-----FLTPVFEALNVSLFPKDTIN 247

  Fly   255 -------RLVVDAMQYREKHNITRPDMIQLLMEAKK----ESKDNWTDDEIVAQCFIFFFAAFEN 308
                   |:....:..::||   |.|.:||:::::.    ||....:|.|:.||..||.||.:|.
Human   248 FLSKSVNRMKKSRLNDKQKH---RLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYET 309

  Fly   309 NSNLICTTAYELLRNLDIQERLYEEVKETQEAL--KGAPLTYDAAQEMTYMDMVISESLRKWTLS 371
            .|:::..|.|||..:.|:|::|.:|:    :|:  ..||.||||..:|.|:|||::|:||.:.::
Human   310 TSSVLSFTLYELATHPDVQQKLQKEI----DAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA 370

  Fly   372 AAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLI- 435
            ...:|.|.||..:..     :| ...|..:.||...||.|.:::.:|:.|.|||||  :|||.|
Human   371 IRLERTCKKDVEING-----VF-IPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS--KKKDSID 427

  Fly   436 PYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRT 478
            ||.|.|||.|||:|||.|:|:|..|..|..::.|:..:....|
Human   428 PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	140/463 (30%)
CYP3A5	NP_000768.1	p450	39..492	CDD:365848	141/468 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1946
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	1	0.950	-	0	Normalized mean entropy	S3417
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.720