Protein Alignment Cyp9b1 and CYP3A4

DIOPT Version :9

• Sequence 1: NP_523645.1
• Gene: Cyp9b1 / 35634
• FlyBaseID: FBgn0015038
• Length: 505
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 497
• Identity: 141/497 - (28%)
• Similarity: 255/497 - (51%)
• Gaps: 56/497 - (11%)

  Fly     4 VEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFYNRTRH 68
            :|..|:||...:||:.:.|.:...|:...:....|.|||||:.:.......|..:..:.|.
Human     9 METWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYG---- 69

  Fly    69 HKLVGLFNLRTPMIQINDPQLIKKICVKD-FDHFPNHQTLNIPNERLVNDMLNVMRDQHWRNMRS 132
             |:.|.::.:.|::.|.||.:||.:.||: :..|.|.:......  .:...:::..|:.|:.:||
Human    70 -KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVG--FMKSAISIAEDEEWKRLRS 131

  Fly   133 VLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVLCNKLSNDVIATTAFGL 197
            :|:|.|||.|::.|..::.:.....:.:|:..     .|....:.:|.:....|.|||.:|:||:
Human   132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE-----AETGKPVTLKDVFGAYSMDVITSTSFGV 191

  Fly   198 KVNSFDDPENEFHTIGKTL--------------AFSRGLPFLKFM-MCLLAPKVFNFFKLTIFDS 247
            .::|.::|::.|....|.|              .|...:|.|:.: :|:...:|.||.:.::
Human   192 NIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSV--- 253

  Fly   248 TNVEYFVRLVVDAMQYREKHNITRPDMIQLLMEAKK----ESKDNWTDDEIVAQCFIFFFAAFEN 308
                  .|:....::..:||   |.|.:||:::::.    ||....:|.|:|||..||.||.:|.
Human   254 ------KRMKESRLEDTQKH---RVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYET 309

  Fly   309 NSNLICTTAYELLRNLDIQERLYEEVKETQEAL--KGAPLTYDAAQEMTYMDMVISESLRKWTLS 371
            .|:::....|||..:.|:|::|.||:    :|:  ..||.|||...:|.|:|||::|:||.:.::
Human   310 TSSVLSFIMYELATHPDVQQKLQEEI----DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA 370

  Fly   372 AAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDLIP 436
            ...:|:|.||..:..     :| ...|..:.||...||.|.:::.:|::|.|||||::.|.::.|
Human   371 MRLERVCKKDVEING-----MF-IPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 429

  Fly   437 YTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRT 478
            |.|.|||.|||:|||.|:|:|..|..|..::.|:..:....|
Human   430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	132/462 (29%)
CYP3A4	NP_059488.2	p450	39..493	CDD:365848	133/467 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1946
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	277	1.000	Inparanoid score	I2940
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.870