DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp9b1 and Cyp4a10

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_034141.3	Gene:	Cyp4a10 / 13117	MGIID:	88611	Length:	509	Species:	Mus musculus

Alignment Length:	524	Identity:	113/524 - (21%)
Similarity:	199/524 - (37%)	Gaps:	133/524 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 MAASALQKASFQKQISEFYNRTRHHKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPN------ 103
            |:.|||....|...:|.|....   .::||..|....:|.   .|.::..:|.|..||:
Mouse     1 MSVSALSPTRFADSLSGFLQVA---SVLGLLLLLVKAVQF---YLHRQWLLKAFQQFPSPPFHWF 59

  Fly   104 --HQTL--------------NIPNE-----------------------------------RLVND 117
              |:..              |.|:.                                   ||:..
Mouse    60 FGHEKFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRSDPKANGAYRLLAP 124

  Fly   118 MLN----VMRDQHWRNMRSVLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDM 178
            .:.    ::..|.|...|.:|||.|....::.....|.:|....|:   ..:.:|..:::.|:..
Mouse   125 WIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLD---KWERLADQDSSIEIFQ 186

  Fly   179 KVLCNKLSNDVIATTAFGLK------------VNSFDDPENEFH-----------TIGKTLAFSR 220
            .:  :.::.|.:...||..|            :.:..|..|.||           ||.|..:..|
Mouse   187 HI--SLMTLDTVMKCAFSHKGSVQVDGNYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGR 249

  Fly   221 GLPFLKFMMCLLAPKVFNFFKLTIFDSTNVEYFVRLVVDAMQ-------YREKHNITRPDMIQLL 278
                |....|.||           .|.|  :..::|..|.:|       .::|.   |.|.:.:|
Mouse   250 ----LAKQACQLA-----------HDHT--DGVIKLRKDQLQDEGELEKIKKKR---RLDFLDIL 294

  Fly   279 MEAKKESKDNWTDDEIVAQCFIFFFAAFENNSNLICTTAYELLRNLDIQERLYEEVKETQEAL-K 342
            :.|:.|:.|:.:|.::.|:...|.|...:..::.:....|.|..:.|.|:|..|||   |..| .
Mouse   295 LFARMENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEV---QSLLGD 356

  Fly   343 GAPLTYDAAQEMTYMDMVISESLRKWTLSAAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICG 407
            |:.:|:|...::.|..|.|.|:||.:.......|..:...|..|  |..|   ..|..:.:.|.|
Mouse   357 GSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPD--GRSL---PKGVQVTLSIYG 416

  Fly   408 LHWDERFFPQPQRFDPERFSERRKKDLIPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKI 472
            ||.:.:.:|.|:.|||.||:....:.  .:::|||..|.|:|||.::|:.:.|.::...:|.:::
Mouse   417 LHHNPKVWPNPEVFDPSRFAPDSPRH--SHSFLPFSGGARNCIGKQFAMSELKVIVALTLLRFEL 479

  Fly   473 EASP 476
            ...|
Mouse   480 LPDP 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	113/524 (22%)
Cyp4a10	NP_034141.3	p450	52..503	CDD:278495	98/467 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900