DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp9b1 and Cyp3a11

DIOPT Version :9

Sequence 1:	NP_523645.1	Gene:	Cyp9b1 / 35634	FlyBaseID:	FBgn0015038	Length:	505	Species:	Drosophila melanogaster
Sequence 2:	NP_031844.1	Gene:	Cyp3a11 / 13112	MGIID:	88609	Length:	504	Species:	Mus musculus

Alignment Length:	525	Identity:	164/525 - (31%)
Similarity:	272/525 - (51%)	Gaps:	60/525 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEF----YN 64
            :|..::||...:||:::.|...:.|:.:.:...||.||||.:       .::.|.:.:|    |.
Mouse     9 LETWVLLAISLVLLYRYGTRKHELFKKQGIPGPKPLPFLGTV-------LNYYKGLWKFDMECYK 66

  Fly    65 RTRHHKLVGLFNLRTPMIQINDPQLIKKICVKD-FDHFPNHQTLNIPNERLVNDMLNVMRDQHWR 128
              ::.|..|||:.:||::.:.||:.||.:.||: |..|.|.:......  :::..:::.:|..|:
Mouse    67 --KYGKTWGLFDGQTPLLAVTDPETIKNVLVKECFSVFTNRRDFGPVG--IMSKAISISKDDEWK 127

  Fly   129 NMRSVLTPVFTSAKMRNMFTLMNESFAQCL-----EHLKSSQPIAAGENAFELDMKVLCNKLSND 188
            ..|::|:|.|||.|::.||.:: |.:...|     :..|..:|:.         ||.:....|.|
Mouse   128 RYRALLSPTFTSGKLKEMFPVI-EQYGDILVKYLRQKAKKGKPVT---------MKDVLGAYSMD 182

  Fly   189 VIATTAFGLKVNSFDDPENEFHTIGKTLA---FSRGLPFLKFMMCLLAPKVFNFFKLTIFDSTNV 250
            ||.:|:||:.|:|.::||:.|....|.|.   |...|.|...:...|.| |:....:.:|...::
Mouse   183 VITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSVVLFPFLTP-VYEMLNICMFPKDSI 246

  Fly   251 EYFVRLVVDAMQ-----YREKHNITRPDMIQLLMEAKKESKDN-----WTDDEIVAQCFIFFFAA 305
            |:|.:. ||.|:     .::||   |.|.:||:|.:...|||.     .:|.||.||..||.||.
Mouse   247 EFFKKF-VDRMKESRLDSKQKH---RVDFLQLMMNSHNNSKDKVSHKALSDMEITAQSIIFIFAG 307

  Fly   306 FENNSNLICTTAYELLRNLDIQERLYEEVKETQEALKG-APLTYDAAQEMTYMDMVISESLRKWT 369
            :|..|:.:..|.:.|..:.|||::|.:|:   .|||.. ||.|||...||.|:|||::|:||.:.
Mouse   308 YETTSSTLSFTLHSLATHPDIQKKLQDEI---DEALPNKAPPTYDTVMEMEYLDMVLNETLRLYP 369

  Fly   370 LSAAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWDERFFPQPQRFDPERFSERRKKDL 434
            ::...:|:|.||..|   .|..:   ..|..:.||...||.|.:.:.:|:.|.|||||:..|..:
Mouse   370 IANRLERVCKKDVEL---NGVYI---PKGSTVMIPSYALHHDPQHWSEPEEFQPERFSKENKGSI 428

  Fly   435 IPYTYLPFGVGPRSCIGNRYAVMQAKGMLYNLMLNYKIEASPRTTRDMWESARGFNIIPTTGFWM 499
            .||.|||||.|||:|:|.|:|:|..|..|..:|.|:..:....|...:..|.:|. :.|.....:
Mouse   429 DPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQIPLKLSRQGL-LQPEKPIVL 492

  Fly   500 QLVSR 504
            ::|.|
Mouse   493 KVVPR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp9b1	NP_523645.1	p450	37..478	CDD:299894	151/464 (33%)
Cyp3a11	NP_031844.1	p450	39..494	CDD:278495	155/490 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	262	1.000	Domainoid score	I1928
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133568
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2821
Isobase	1	0.950	-	0	Normalized mean entropy	S3417
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8813
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.720