DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp42Er and CD63

DIOPT Version :9

Sequence 1:	NP_523644.1	Gene:	Tsp42Er / 35629	FlyBaseID:	FBgn0033139	Length:	211	Species:	Drosophila melanogaster
Sequence 2:	NP_001244318.1	Gene:	CD63 / 967	HGNCID:	1692	Length:	238	Species:	Homo sapiens

Alignment Length:	224	Identity:	56/224 - (25%)
Similarity:	101/224 - (45%)	Gaps:	45/224 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LMIRYLAFLFNFLCAV----LGIATIVVNVIAIDQIAPKDQLILGLYIAVGSIVFLLSFFGCFGA 66
            |.:..|||.   .|||    :|:...:|....|.|.|....|:..:.||||..:||::|.||.||
Human    14 LYVLLLAFC---ACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGA 75

  Fly    67 IKESIC--VTWAYATSMLVML-IVSIVMLFVFR---MHFEEDSITKLKQAFAKQTNTFDAMAEYQ 125
            .||:.|  :|:|...|::::: :.:.:..:|||   |....::..:..:.:.|..:|...:...|
Human    76 CKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQ 140

  Fly   126 TQYQCCGIYKLKDY----GDAYITVPSSC---------YDQNDTP-YRDGCLAKMETQYEELLKG 176
            ..::|||.....|:    ..:...||.||         .:.|:.. :::||:
Human   141 ADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKEGCV------------- 192

  Fly   177 PKIVGWM---LMVIEIGA--FTFSTIMGV 200
            .||.||:   ::|:...|  ..|..::|:
Human   193 EKIGGWLRKNVLVVAAAALGIAFVEVLGI 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Er	NP_523644.1	Tetraspannin	8..195	CDD:278750	53/215 (25%)
Tsp42Er	NP_523644.1	tetraspanin_LEL	93..174	CDD:239401	18/97 (19%)
CD63	NP_001244318.1	Tetraspannin	10..227	CDD:395265	56/224 (25%)
		CD63_LEL	105..203	CDD:239419	22/110 (20%)
		Lysosomal targeting motif. /evidence=ECO:0000250\|UniProtKB:P41731	234..238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810