DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant3 and Galntl5

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_080725.2	Gene:	Galntl5 / 67909	MGIID:	1915159	Length:	431	Species:	Mus musculus

Alignment Length:	452	Identity:	168/452 - (37%)
Similarity:	257/452 - (56%)	Gaps:	36/452 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LKKLWLLYLFLLFFAFFMFAISINLYVASIQGGDAEMRHPKPPPKRRSLWPHKNIVAHYIGKGDI 72
            :|.:.:..||..|.|..::|..:.|:: .::..|......:...|:|||  .||  ||...:..
Mouse     1 MKSVIIQGLFCGFLAIGLWASMLLLFL-HLEQEDMLENEKEELLKKRSL--GKN--AHQQTRHS- 59

  Fly    73 FGNMTADDYNINLFQPINGEGADGRPVVVPPRDRFRMQRFFRLNSFNLLASDRIPLNRTLKDYRT 137
             .::|.|:.|.:..:.|.|                 ::|:    ..|.:.|.|:.:.|.:.|.|.
Mouse    60 -EDVTHDEVNFSDPELIQG-----------------LRRY----GLNAIMSRRLGIEREVPDSRD 102

  Fly   138 PECRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLE 202
            ..|:.|.|...||:.|:||.|:||.::.|||.::||:|.||:|||:|||||||.|:...||.:|:
Mouse   103 KICQQKHYPFNLPTASIIICFYNEEFNTLLRAVSSVVNLSPQHLLEEIILVDDMSEFDDLKDKLD 167

  Fly   203 SYVKVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVV 267
            .|:::.....::.|.|||.||:.::::||..|.||:|.|||:|||.:|.||||||..|.:..|:|
Mouse   168 YYLEIFRGKVKLIRNKKREGLIRSKMIGASRASGDILVFLDSHCEVNRVWLEPLLHAIAKDHKMV 232

  Fly   268 ICPVIDIISDDNFSYTKTFENHWGAFNWQLSFRWFSSDRKRQTAGNSSKDSTDPIATPGMAGGLF 332
            :||:||:|::....|... ....|||:|.|:.||   |.......:..:..:.||.:|.|.||:|
Mouse   233 VCPIIDVINELTLDYMAA-PIVRGAFDWNLNLRW---DNVFAYELDGPEGPSTPIRSPAMTGGIF 293

  Fly   333 AIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEV 397
            ||:|.||.|:|.||:.|.:.||||||:|.|||.|||::.|.|||.||:..::.:.:.  ......
Mouse   294 AINRHYFNELGQYDNGMDICGGENVELSLRIWMCGGQLFILPCSRVGYNSKALSQHR--RANQSA 356

  Fly   398 LTDNLARAATVWMDDWQYFIMLYTSGLTLGAKDKVNVTERVALRERLQCKPFSWYLENIWPE 459
            |:.||.|...||:|:::....|....||..:..  |::|||.||:||.||.|.|||:||:||
Mouse   357 LSRNLLRVVHVWLDEYKGNFFLQRPSLTYVSCG--NISERVELRKRLGCKSFQWYLDNIFPE 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	108/235 (46%)
		pp-GalNAc-T	153..457	CDD:133004	132/303 (44%)
		Ricin_B_lectin	516..658	CDD:279046
		RICIN	524..660	CDD:238092
Galntl5	NP_080725.2	Catalytic subdomain A	114..224		56/109 (51%)
		pp-GalNAc-T	118..414	CDD:133004	132/303 (44%)
		Glyco_tranf_2_2	118..380	CDD:287123	115/267 (43%)
		Catalytic subdomain B	282..344		36/61 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820