DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant3 and GALNT17

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_071924.1	Gene:	GALNT17 / 64409	HGNCID:	16347	Length:	598	Species:	Homo sapiens

Alignment Length:	644	Identity:	210/644 - (32%)
Similarity:	311/644 - (48%)	Gaps:	107/644 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLYLFLLFFAFFMFAISINLYVA-----SIQGGDA--EMR----------HPKPP-----PKRRS 55
            ||.|.|:..|.|:      |::|     :::.|||  |:|          |...|     .||.|
Human    10 LLVLNLIAVAGFV------LFLAKCRPIAVRSGDAFHEIRPRAEVANLSAHSASPIQDAVLKRLS 68

  Fly    56 LWPHKNIVAHYIGKGDIFGNMTADDYNINLFQPINGEGADGRPVVVPPRDRFRMQRFFRLNSFNL 120
            |.  ::||         :..:.....::.|.:...|.|..|.|..:.|.:..:.:.......:|.
Human    69 LL--EDIV---------YRQLNGLSKSLGLIEGYGGRGKGGLPATLSPAEEEKAKGPHEKYGYNS 122

  Fly   121 LASDRIPLNRTLKDYRTPECRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEI 185
            ..|::|.|:|::.|||..:|::.||:..||..|:|.:|.|||.||:||::.|.:|.:|.||||||
Human   123 YLSEKISLDRSIPDYRPTKCKELKYSKDLPQISIIFIFVNEALSVILRSVHSAVNHTPTHLLKEI 187

  Fly   186 ILVDDASDRSYLKRQLESYV-KVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFLDAHCECS 249
            |||||.||...||..||.|| |......::.|.:||.||:.||:.|.:.|.|.|..|.|||.|.:
Human   188 ILVDDNSDEEELKVPLEEYVHKRYPGLVKVVRNQKREGLIRARIEGWKVATGQVTGFFDAHVEFT 252

  Fly   250 RGWLEPLLSRIKESRKVVICPVIDIISDDNFSYTKTFENHWGAFNWQLSFRWFSSDRKRQTAGNS 314
            .||.||:||||:|:||.||.|.||.|..|||. .:.:||....::|:|...:.|..:....||
Human   253 AGWAEPVLSRIQENRKRVILPSIDNIKQDNFE-VQRYENSAHGYSWELWCMYISPPKDWWDAG-- 314

  Fly   315 SKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVG 379
              |.:.||.||.|.|..|.::||:|.|:|..|..|.|:||||:|:..::|.|||.:|:.|||.|.
Human   315 --DPSLPIRTPAMIGCSFVVNRKFFGEIGLLDPGMDVYGGENIELGIKVWLCGGSMEVLPCSRVA 377

  Fly   380 HVFRSSTPYTFPGGMSEVLTDNLARAATVWMDDWQ------YFIMLYTSGLTLGAKDKVNVTERV 438
            |:.|...||.  ..:......|..|.|.|||||::      :.:.|...|:.:|     :|:||.
Human   378 HIERKKKPYN--SNIGFYTKRNALRVAEVWMDDYKSHVYIAWNLPLENPGIDIG-----DVSERR 435

  Fly   439 ALRERLQCKPFSWYLENIWPEHFFPAPDRF-----FGKI-------IWLDG---ETECAQAYSKH 488
            |||:.|:||.|.|||::::||     ..|:     :|::       :.||.   |...|..|..|
Human   436 ALRKSLKCKNFQWYLDHVYPE-----MRRYNNTVAYGELRNNKAKDVCLDQGPLENHTAILYPCH 495

  Fly   489 MKNLPGRALSREWKRAFEEIDSKAEELMALIDLERDKCLRPLKEDVPRSSLSAVTVGDCTSHAQS 553
            ..   |..|:|..|..|..:.:.....:    |...:||    .|..:|.|..:.  ||.....|
Human   496 GW---GPQLARYTKEGFLHLGALGTTTL----LPDTRCL----VDNSKSRLPQLL--DCDKVKSS 547

  Fly   554 M-DMFVITPKGQIMT-NDNVCLTYRQQKLGVIKMLKNRNATTSNVMLAQCASDSSQLWT 610
            : ..:.....|.||. ....||.           ::||.....:::|..|   :.|.||
Human   548 LYKRWNFIQNGAIMNKGTGRCLE-----------VENRGLAGIDLILRSC---TGQRWT 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	109/236 (46%)
		pp-GalNAc-T	153..457	CDD:133004	134/310 (43%)
		Ricin_B_lectin	516..658	CDD:279046	21/97 (22%)
		RICIN	524..660	CDD:238092	20/89 (22%)
GALNT17	NP_071924.1	Catalytic subdomain A	151..262		56/110 (51%)
		pp-GalNAc-T	155..454	CDD:133004	134/310 (43%)
		Catalytic subdomain B	319..381		30/61 (49%)
		RICIN	467..593	CDD:238092	33/153 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810