DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant3 and galnt6

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_998361.1	Gene:	galnt6 / 406477	ZFINID:	ZDB-GENE-040426-2272	Length:	619	Species:	Danio rerio

Alignment Length:	559	Identity:	223/559 - (39%)
Similarity:	305/559 - (54%)	Gaps:	89/559 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 GADGRPV----VVPPRDRFRMQRFFRLNSFNLLASDRIPLNRTL-KDYRTPECRDKKY--ASGLP 150
            ||||.|.    :....::.:.:...| :.||..|||||.|:||| .|.|.|||.|:|:  ...||
Zfish   109 GADGVPFQYDRMTKEEEKEKQEGMTR-HCFNQFASDRISLHRTLGDDTRPPECVDRKFRRCPALP 172

  Fly   151 STSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIF 215
            :|||||||||||||.||||:.||::.||...|||||:|||||...:|..:||.|||.|.: .::.
Zfish   173 TTSVIIVFHNEAWSTLLRTVYSVLHTSPAAFLKEIIMVDDASTAEHLHGKLEEYVKALKI-VKVV 236

  Fly   216 RMKKRSGLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVICPVIDIISDDNF 280
            |..:|.||:.||||||..|.|::||||||||||..|||||||:||.|....|:.|.|..|..:.|
Zfish   237 RQPERKGLITARLLGASKAEGEILTFLDAHCECFHGWLEPLLARIVEEPTAVVSPEITTIDLNTF 301

  Fly   281 SYTK---TFENH-WGAFNWQLSFRWFS----SDRKRQTAGNSSKDSTDPIATPGMAGGLFAIDRK 337
            .:.|   |...| .|.|:|.|:|.|..    .:.||       ||.|.|:.||..|||||:|.:.
Zfish   302 QFHKPVATARAHNRGNFDWSLTFGWEGIPDYENAKR-------KDETYPVKTPTFAGGLFSISKA 359

  Fly   338 YFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNL 402
            ||.::|:||..|.:|||||||||||:|||||::||.|||.||||||:.:|:|||.| :||:|.|.
Zfish   360 YFEKIGTYDDKMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKG-TEVITRNQ 423

  Fly   403 ARAATVWMDDWQYFIMLYTSGLTLGAKDK--VNVTERVALRERLQCKPFSWYLENIWPEHFFP-- 463
            .|.|.|||||::......:......||:|  .::::|:.|||.||||.|||||.|::||.|.|
Zfish   424 VRLAEVWMDDYKLIFYRRSQSAAKMAKEKGFGDISDRLKLREDLQCKNFSWYLSNVYPEAFVPDL 488

  Fly   464 APDRFFGKIIWLDGETECAQA------------YSKHMKNLPGRALSREWKRAFEEIDSKAEELM 516
            :|.:|  ..:...|..:|...            |:.|  |:.|       .:.||....|  ||.
Zfish   489 SPVKF--GALKNRGAQQCLDVGESNNGGKPVIMYTCH--NMGG-------NQYFEYTSHK--ELR 540

  Fly   517 ALIDLERDKCLR--PLKEDVPRSSLSAVTVGDCTSHAQSMDMFVITPKGQIMTNDNVCLTYRQQK 579
            .  ::.:..||:  |..|.|                  .:::..:..||..:..:...|...:|
Zfish   541 H--NIGKQLCLQASPYPEPV------------------KIELCTLKGKGSSLAPEQEWLITEEQ- 584

  Fly   580 LGVIKMLKNRNA------TTSNVMLAQC-ASDSSQLWTY 611
                 :|||.::      ....::::.| ..|..|.|.:
Zfish   585 -----LLKNPSSGKCLHKKGDKILMSPCNPDDHHQQWAF 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	132/243 (54%)
		pp-GalNAc-T	153..457	CDD:133004	163/313 (52%)
		Ricin_B_lectin	516..658	CDD:279046	16/105 (15%)
		RICIN	524..660	CDD:238092	16/97 (16%)
galnt6	NP_998361.1	pp-GalNAc-T	175..480	CDD:133004	163/313 (52%)
		Ricin_B_lectin	493..616	CDD:279046	27/161 (17%)
		RICIN	494..618	CDD:238092	27/160 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920