Protein Alignment Pgant3 and GALNT18

DIOPT Version :9

• Sequence 1: NP_610256.1
• Gene: Pgant3 / 35627
• FlyBaseID: FBgn0027558
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_940918.2
• Gene: GALNT18 / 374378
• HGNCID: 30488
• Length: 607
• Species: Homo sapiens
• Alignment Length: 671
• Identity: 206/671 - (30%)
• Similarity: 307/671 - (45%)
• Gaps: 154/671 - (22%)

  Fly    33 YVASIQGGDAEMRHPKPPPKRRSLWPHKNIVAHYIGKGDIFGNMTADDYNINLFQ------PING 91
            |:||:.     :|..:|.|.::.          ...|||....:...|:..|:.:      |...
Human    35 YIASVY-----VRGQEPAPDKKL----------EEDKGDTLKIIERLDHLENVIKQHIQEAPAKP 84

  Fly    92 EGADGRPVV-----------VPPRDRFRMQRFFRLNSFNLLASDRIPLNRTLKDYRTPECRDKKY 145
            |.|:..|..           :.|..|....:.|:...:|...|||:||:|.|.|.|...||:..:
Human    85 EEAEAEPFTDSSLFAHWGQELSPEGRRVALKQFQYYGYNAYLSDRLPLDRPLPDLRPSGCRNLSF 149

  Fly   146 ASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLESYV-KVLA 209
            ...||..|::.:|.|||.|||||:|.|.:.|:|.|||||||||||.|....||.:|..|| ||.:
Human   150 PDSLPEVSIVFIFVNEALSVLLRSIHSAMERTPPHLLKEIILVDDNSSNEELKEKLTEYVDKVNS 214

  Fly   210 VP---TRIFRMKKRSGLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVICPV 271
            ..   .::.|..|:.||:.:|:.|...|...|:...|||.|.:.||.||:|:||||:||.:|.|.
Human   215 QKPGFIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRIISPS 279

  Fly   272 IDIISDDNF---SYTKTFENHWGAFNWQLSFRWFSSDRKRQTAGNSSKDSTDPIATPGMAGGLFA 333
            .|.|..|||   .|....:    .|:|:|..|:.:..:    |....::||.||.:|.:. |.|.
Human   280 FDNIKYDNFEIEEYPLAAQ----GFDWELWCRYLNPPK----AWWKLENSTAPIRSPALI-GCFI 335

  Fly   334 IDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVL 398
            :||:||.|:|..|..|.|:||||||:..|:|||||.||:.|||.:.|:.|:..|||      |.|
Human   336 VDRQYFQEIGLLDEGMEVYGGENVELGIRVWQCGGSVEVLPCSRIAHIERAHKPYT------EDL 394

  Fly   399 T----DNLARAATVWMDDWQYFIML------YTSGLTLGAKDKVNVTERVALRERLQCKPFSWYL 453
            |    .|..|.|.||||:::..:.:      ..||:.:|     ::|.|.|||::||||.|.|||
Human   395 TAHVRRNALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIG-----DITARKALRKQLQCKTFRWYL 454

  Fly   454 ENIWPEHFFPAPDRFFGKIIWLDGETECAQAYSKHMKNLPGRALSREWKRAFEEIDSKAEELMAL 518
            .:::||.      |.:..||          ||.. ::|
Human   455 VSVYPEM------RMYSDII----------AYGV-LQN--------------------------- 475

  Fly   519 IDLERDKCL--RPLKEDVPRSSLSAVTVGDCTSH-----AQSMDMFVITPKGQIMTNDNVCLTYR 576
             .|:.|.||  .|..|:||   :..:..|....:     :|.:.:.:::|  .:..:||.||.
Human   476 -SLKTDLCLDQGPDTENVP---IMYICHGMTPQNVYYTSSQQIHVGILSP--TVDDDDNRCLV-- 532

  Fly   577 QQKLGVIKMLKNRNATTSNVMLAQCASDSSQL----WTYDMDTQQISHRDTKLCLTLKAATNSRL 637
                          ...|...|.:|:...::.    |.:... ..|.:|.:|.||.|:  .||.|
Human   533 --------------DVNSRPRLIECSYAKAKRMKLHWQFSQG-GPIQNRKSKRCLELQ--ENSDL 580

  Fly   638 QKVEKVVLSMECDFKDITQKW 658
            :...::|| .:|.    .|.|
Human   581 EFGFQLVL-QKCS----GQHW 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	105/242 (43%)
		pp-GalNAc-T	153..457	CDD:133004	133/320 (42%)
		Ricin_B_lectin	516..658	CDD:279046	32/152 (21%)
		RICIN	524..660	CDD:238092	32/146 (22%)
GALNT18	NP_940918.2	Catalytic subdomain A	153..267		52/113 (46%)
		pp-GalNAc-T	157..458	CDD:133004	133/320 (42%)
		Catalytic subdomain B	324..385		32/61 (52%)
		RICIN	471..598	CDD:238092	34/184 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810