DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant3 and Galnt3

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001015032.2	Gene:	Galnt3 / 366061	RGDID:	1306443	Length:	633	Species:	Rattus norvegicus

Alignment Length:	705	Identity:	241/705 - (34%)
Similarity:	335/705 - (47%)	Gaps:	146/705 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KKLWLLYLFLLFFAFFMFAISINLYVASIQGGDAEMRHPKPPPKRRSLWPHKNIVAHY------- 66
            :|.|.|...:.||          |.|..:...:..:::.|...|......:||.:..:
  Rat    18 RKFWKLGAVIFFF----------LVVLILMQREVSVQYSKEESKMERNLKNKNKMFDFMLEAVNN 72

  Fly    67 ---------IG-----------KGDIFGNMTADDYNINLFQP---INGEGADGRPVVV---PPRD 105
                     ||           :..:.|..||.:....|.:|   .|..||.|:|..:   .|.:
  Rat    73 IKDAMPKMQIGAPIKQNIDVPERPCLQGYYTAAELKPVLDRPPQDSNAPGASGKPFKITHLSPEE 137

  Fly   106 RFRMQRFFRLNSFNLLASDRIPLNRTL-KDYRTPECRDKKY--ASGLPSTSVIIVFHNEAWSVLL 167
            :...:|....:.||..|||||.|:|.| .|.|.|||.::|:  ...||:|||||||||||||.||
  Rat   138 QKEKERGETKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHNEAWSTLL 202

  Fly   168 RTITSVINRSPRHLLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRSGLVPARLLGAE 232
            ||:.||:..||..||||||||||||...||..:||.|:|..:: .:|.|.::|.||:.||||||.
  Rat   203 RTVHSVLYSSPAILLKEIILVDDASVDDYLHEKLEEYIKQFSI-VKIVRQQERKGLITARLLGAA 266

  Fly   233 NARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVICPVIDIISDDNFSYTKTF---ENH-WGAF 293
            .|..:.||||||||||..|||||||:||.|:...|:.|.|..|..:.|.:.|..   .|| .|.|
  Rat   267 VATAETLTFLDAHCECFYGWLEPLLARIAENYTAVVSPDIASIDLNTFEFNKPSPYGSNHNRGNF 331

  Fly   294 NWQLSFRWFS-SDRKRQTAGNSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENV 357
            :|.|||.|.| .|.::|    ..||.|.||.||..|||||:|.|.||..:||||..|.:|||||:
  Rat   332 DWSLSFGWESLPDHEKQ----RRKDETYPIKTPTFAGGLFSISRDYFEHIGSYDEEMEIWGGENI 392

  Fly   358 EMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNLARAATVWMDDWQYFIMLYTS 422
            |||||:|||||::||.|||.|||||||.:|:|||.| ::|:..|..|.|.||||:::.......:
  Rat   393 EMSFRVWQCGGQLEIMPCSVVGHVFRSKSPHTFPKG-TQVIARNQVRLAEVWMDEYKEIFYRRNT 456

  Fly   423 GLTLGAKDKV--NVTERVALRERLQCKPFSWYLENIWPEHFFPAPDRFFGKIIWLDGETECAQAY 485
            ......|.|.  ::::|..:::|||||.|:|||..|:||.:.|                :.....
  Rat   457 DAAKIVKQKSFGDLSKRFEIKKRLQCKNFTWYLNTIYPEVYVP----------------DLNPVI 505

  Fly   486 SKHMKNLPGRALSREWKRAFEEIDSKAEELMALIDLERDKCLRPLKEDVPRSSLSAVTVGDCTSH 550
            |.::|::.                                  :||..||..::.....:...|.|
  Rat   506 SGYIKSVG----------------------------------QPLCLDVGENNQGDKPLILYTCH 536

  Fly   551 AQSMDM-FVITPKGQIMTN--DNVCLTYRQQKLGVIKMLKNRNATTSNVMLAQCA-------SDS 605
            ....:. |..:.:.:|..|  ..:||                :||...|.|..|.       :..
  Rat   537 GLGGNQYFEYSAQREIRHNIQKELCL----------------HATQGVVQLKACVYKGHRTIAPG 585

  Fly   606 SQLWTYDMDTQQISHRDTKLCLTLKAATNSRLQKVEKVVLSMECDFKDITQKWGF 660
            .|:|....| |.:.:...::||:......|          .:.||..|:.|||.|
  Rat   586 EQIWEIRKD-QLLYNPLFRMCLSSNGEHPS----------LVPCDTTDLLQKWIF 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	138/240 (58%)
		pp-GalNAc-T	153..457	CDD:133004	161/310 (52%)
		Ricin_B_lectin	516..658	CDD:279046	27/151 (18%)
		RICIN	524..660	CDD:238092	29/145 (20%)
Galnt3	NP_001015032.2	pp-GalNAc-T	188..493	CDD:133004	161/310 (52%)
		Ricin_B_lectin	506..627	CDD:279046	29/181 (16%)
		RICIN	507..629	CDD:238092	30/182 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920