DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant3 and Galnt11

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001258248.1	Gene:	Galnt11 / 311952	RGDID:	735097	Length:	609	Species:	Rattus norvegicus

Alignment Length:	675	Identity:	225/675 - (33%)
Similarity:	340/675 - (50%)	Gaps:	118/675 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 WLLYLFLLFFAFFMFA-ISINLYVASIQGGDAEMRHPKPPPKRRSLWPHKNIVAHYIGKGDIFGN 75
            |.:.||:    :|.|: ::..|....|:|.......||....|.:..|.:.:...:      ..|
  Rat    21 WTVLLFI----YFNFSEVTQPLRNVPIKGSGPHGPFPKKFYPRFTRGPGRVLEPQF------KAN 75

  Fly    76 MTADDYNINLFQPING--EGADGRPVVVPPRDRFRMQRFFRLNSFNLLASDRIPLNRTLKDYRTP 138
            ...|..|.|:..|..|  :.:....::...||:......::.::||:|.|:|:..:|.:.|.|..
  Rat    76 RMDDLMNNNIEDPDKGLSKSSSELGMIFNERDQELRDLGYQKHAFNMLISNRLGYHRDVPDTRNA 140

  Fly   139 ECRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLES 203
            |||.|.|.:.||:.||:|.|:|||:|.||||:.||::|:|.|||.|||||||:||...||.:|:.
  Rat   141 ECRGKSYPTDLPTASVVICFYNEAFSALLRTVHSVVDRTPAHLLHEIILVDDSSDFDDLKGELDE 205

  Fly   204 YV-KVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVV 267
            |: :.|....::.|..||.||:..|::||.:|.|:||.|||:|||.:..||:|||:.|.|....|
  Rat   206 YIQRYLPAKVKVIRNMKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAIILEDPHTV 270

  Fly   268 ICPVIDIISDDNFSYTKTFENHWGAFNWQLSFRWFSSDRKRQTAGNSSKDSTDPIATPGMAGGLF 332
            :||||||||.|..:|:.:.... |.|||.|.|:|   |....:....:..:|.||.:|.||||||
  Rat   271 VCPVIDIISADTLAYSSSPVVR-GGFNWGLHFKW---DLVPVSDLGGADSATAPIRSPTMAGGLF 331

  Fly   333 AIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEV 397
            |::|:||.::|.|||.|.:|||||:|:|||||.|||::.|.|||.|||:||...||..|.| .:.
  Rat   332 AMNRQYFNDLGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEG-QDT 395

  Fly   398 LTDNLARAATVWMDDW--QYFIMLYTSGLTLGAKDKVNVTERVALRERLQCKPFSWYLENIWPEH 460
            :|.|..|.|.||:|::  |||.:    ...|..|...|::|||.||::|.|:.|.|||:|::||.
  Rat   396 MTHNSLRLAHVWLDEYKEQYFSL----RPDLKTKSFGNISERVELRKKLGCQSFKWYLDNVYPEM 456

  Fly   461 FFPAPDRFFGKIIWLDGETECAQAYSKHMKNLPGRALSREWKRAFEEIDSKAEELMALIDLERDK 525
            ....|.....:.::::      :...:....|.||                      |..|:.:|
  Rat   457 QVSGPKARLQQPVFIN------RGPKRPRVLLRGR----------------------LYHLQTNK 493

  Fly   526 CLRPLKEDVPRSS-------LSAVTVGDCTSHAQSMDMFVITPKGQIMTNDNVCLTYRQQKLGVI 583
            ||    ....|||       |.|...||.|      .:::...:.:::.|:.:||
  Rat   494 CL----VAQGRSSQKGGLVLLKACDYGDPT------QVWIYNEEHELILNNLLCL---------- 538

  Fly   584 KMLKNRNATTSNVMLAQC-ASDSSQLWTYDMDTQQISHRDTKLCLTLKAATNSRLQKVE-----K 642
            .|.:.|::....:|  :| .|..||.||:                    ..|:||.:|.     :
  Rat   539 DMSETRSSDPPRLM--KCHGSGGSQQWTF--------------------GKNNRLYQVSVGQCLR 581

  Fly   643 VVLSME---------CDFKDITQKW 658
            ||..|:         ||... :|:|
  Rat   582 VVDQMDQKGYVGMAICDGSS-SQQW 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	120/236 (51%)
		pp-GalNAc-T	153..457	CDD:133004	148/306 (48%)
		Ricin_B_lectin	516..658	CDD:279046	35/163 (21%)
		RICIN	524..660	CDD:238092	34/157 (22%)
Galnt11	NP_001258248.1	pp-GalNAc-T	155..453	CDD:133004	148/306 (48%)
		Glyco_tranf_2_3	155..383	CDD:290369	118/231 (51%)
		Ricin_B_lectin	484..605	CDD:279046	37/185 (20%)
		RICIN	488..607	CDD:238092	35/161 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820