DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant3 and Galnt7

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_075215.1	Gene:	Galnt7 / 29750	RGDID:	620362	Length:	657	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	191/621 - (30%)
Similarity:	294/621 - (47%)	Gaps:	136/621 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 IFGNMTADDYNINLFQP--------INGEGADGRPVVVPPRDRFRMQRFFRLNSFNLLASDRIPL 128
            :.||          |:|        :.|.|.:.:|:|:.|..:...|...:...||:.|||.|.|
  Rat   131 VLGN----------FEPKEPEPHGVVGGPGENAKPLVLGPEYKQAAQASIKEFGFNMAASDMISL 185

  Fly   129 NRTLKDYRTPECRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASD 193
            :|::.|.|..||:...|...|.::||:||||||.||.|:||:.|||.|:||..|.||:|:||.|:
  Rat   186 DRSVNDLRQEECKYWHYDENLLTSSVVIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSN 250

  Fly   194 RSYLKRQLESYVKVLAVPTRIFRMKKRSGLVPARLLGAENAR-GDVLTFLDAHCECSRGWLEPLL 257
            :.:||.:|..|:|:.....::||.::|.||:.||.:||:.|: |.||.:||||||.:..|..||:
  Rat   251 KEHLKEKLTEYIKLWNGLVKVFRNERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLV 315

  Fly   258 SRIKESRKVVICPVIDIISDDNF-----------SYTKTFENHWGAFNWQLSFRW----FSSDRK 307
            :.|.:.|.:...|:||:|:.:.:           .|.:      ||::|  |..|    .:...|
  Rat   316 APISKDRTICTVPIIDVINGNTYEIIPQGGGDEDGYAR------GAWDW--SMLWKRVPLTPREK 372

  Fly   308 RQTAGNSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEI 372
            |     ..|..|:|..:|.||||||||:|.:|:|:|.||..:::|||||.|:|::||||||::..
  Rat   373 R-----LRKTKTEPYRSPAMAGGLFAIERDFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLF 432

  Fly   373 SPCSHVGHVFR-----SSTPYTFPGGMSEVLTDNLARAATVWMDDWQ-YFIMLYTSGLTLGAKDK 431
            .|||.|||::|     .:.|..:.|  |.....|..|...||.|::: ||   |.|.....|...
  Rat   433 VPCSRVGHIYRLEGWQGNPPPLYVG--SSPTLKNYVRVVEVWWDEYKDYF---YASRPESKALPY 492

  Fly   432 VNVTERVALRERLQCKPFSWYLENIWPE---HFFPAPDRFFGKIIWLDGETECAQAYSKHMKNLP 493
            .:::|....||...||.|.|::|.|..:   | :|.|.|   .:.|  ||
  Rat   493 GDISELKKFREDHNCKSFKWFMEEIAYDITAH-YPLPPR---NVEW--GE--------------- 536

  Fly   494 GRALSREWKRAFEEIDSKAEELMALIDLERDKCLRPLKEDVPRSSLSAVTVGDCTSHAQ-SMDMF 557
                                    :..||...|:    :.:.:::...|.:|.|  |.. ...:|
  Rat   537 ------------------------IRGLETAYCI----DSMGKTNGGFVELGPC--HRMGGNQLF 571

  Fly   558 VITPKGQIMTNDNVCLTYRQQKLGVIKMLKNRNATTSNVMLAQCASDSSQLWTYDMDTQQISHRD 622
            .|....|:|..|. |||              :....|.||:..|..:..:.|.|..:..:.:|..
  Rat   572 RINEANQLMQYDQ-CLT--------------KGPDGSKVMITHCNLNEFKEWQYFKNLHRFTHIA 621

  Fly   623 TKLCLTLKAATNSRLQKVEKVVLSMECDFKDITQKW 658
            :..||       .|.:.:.:|.:| .||...:||||
  Rat   622 SGKCL-------DRSEVLHQVFIS-SCDNGKMTQKW 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	105/256 (41%)
		pp-GalNAc-T	153..457	CDD:133004	126/325 (39%)
		Ricin_B_lectin	516..658	CDD:279046	31/142 (22%)
		RICIN	524..660	CDD:238092	31/136 (23%)
Galnt7	NP_075215.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..66
		Catalytic subdomain A	206..317		54/110 (49%)
		pp-GalNAc-T	210..518	CDD:133004	126/325 (39%)
		WcaA	210..>331	CDD:223539	56/120 (47%)
		Catalytic subdomain B	381..443		35/61 (57%)
		Ricin_B_lectin	534..649	CDD:279046	34/184 (18%)
		RICIN	535..651	CDD:238092	35/183 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820