Protein Alignment Pgant3 and GALNT3

DIOPT Version :9

• Sequence 1: NP_610256.1
• Gene: Pgant3 / 35627
• FlyBaseID: FBgn0027558
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_004473.2
• Gene: GALNT3 / 2591
• HGNCID: 4125
• Length: 633
• Species: Homo sapiens
• Alignment Length: 698
• Identity: 242/698 - (34%)
• Similarity: 331/698 - (47%)
• Gaps: 136/698 - (19%)

  Fly     9 KKLWLLYLFLLFFAFFMFAISINLYVASIQGGDAEMRHPKPPPKRRSL--------------WPH 59
            ||.|.|...:.||...:..:...:   |:|....|.|..:....:..:              .|.
Human    18 KKFWKLGAVIFFFIIVLVLMQREV---SVQYSKEESRMERNMKNKNKMLDLMLEAVNNIKDAMPK 79

  Fly    60 KNI---VAHYIGKGD---IFGNMTADDYNINLFQP---INGEGADG---RPVVVPPRDRFRMQRF 112
            ..|   |...|..|:   :.|..||.:....|.:|   .|..||.|   :...:...::...:|.
Human    80 MQIGAPVRQNIDAGERPCLQGYYTAAELKPVLDRPPQDSNAPGASGKAFKTTNLSVEEQKEKERG 144

  Fly   113 FRLNSFNLLASDRIPLNRTL-KDYRTPECRDKKY--ASGLPSTSVIIVFHNEAWSVLLRTITSVI 174
            ...:.||..|||||.|:|.| .|.|.|||.::|:  ...||:|||||||||||||.||||:.||:
Human   145 EAKHCFNAFASDRISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHNEAWSTLLRTVHSVL 209

  Fly   175 NRSPRHLLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRSGLVPARLLGAENARGDVL 239
            ..||..||||||||||||...||..:|:.|||..:: .:|.|.::|.||:.||||||..|..:.|
Human   210 YSSPAILLKEIILVDDASVDEYLHDKLDEYVKQFSI-VKIVRQRERKGLITARLLGATVATAETL 273

  Fly   240 TFLDAHCECSRGWLEPLLSRIKESRKVVICPVIDIISDDNFSYTKTF---ENH-WGAFNWQLSFR 300
            |||||||||..|||||||:||.|:...|:.|.|..|..:.|.:.|..   .|| .|.|:|.|||.
Human   274 TFLDAHCECFYGWLEPLLARIAENYTAVVSPDIASIDLNTFEFNKPSPYGSNHNRGNFDWSLSFG 338

  Fly   301 WFS-SDRKRQTAGNSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRIW 364
            |.| .|.::|    ..||.|.||.||..|||||:|.::||..:||||..|.:|||||:|||||:|
Human   339 WESLPDHEKQ----RRKDETYPIKTPTFAGGLFSISKEYFEYIGSYDEEMEIWGGENIEMSFRVW 399

  Fly   365 QCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNLARAATVWMDDWQYFIMLYTSGLTLGAK 429
            ||||::||.|||.|||||||.:|::||.| ::|:..|..|.|.||||:::.......:......|
Human   400 QCGGQLEIMPCSVVGHVFRSKSPHSFPKG-TQVIARNQVRLAEVWMDEYKEIFYRRNTDAAKIVK 463

  Fly   430 DKV--NVTERVALRERLQCKPFSWYLENIWPEHFFPAPDRFFGKIIWLDGETECAQA-------- 484
            .|.  ::::|..::.|||||.|:|||.||:||.:.|..:......|...|:..|...
Human   464 QKAFGDLSKRFEIKHRLQCKNFTWYLNNIYPEVYVPDLNPVISGYIKSVGQPLCLDVGENNQGGK 528

  Fly   485 ----YSKHMKNLPGRALSREWKRAFEEIDSKAEELMALIDLERDKCLRPLKEDVPRSSLSAVTVG 545
                |:.|  .|.|       .:.||.  |...|:..  :::::.||
Human   529 PLIMYTCH--GLGG-------NQYFEY--SAQHEIRH--NIQKELCL------------------ 562

  Fly   546 DCTSHAQSMDMFVITPKGQIMTNDNVCLTYRQQKLGVIKMLKNRNATTSNVMLAQCASDSSQLWT 610
                ||           .|.:.....| ||:..|..|                     ...|:|.
Human   563 ----HA-----------AQGLVQLKAC-TYKGHKTVV---------------------TGEQIWE 590

  Fly   611 YDMDTQQISHRDTKLCLTLKAATNSRLQKVEKVVLSMECDFKDITQKW 658
            ...| |.:.:...|:||:......|          .:.|:..|..|||
Human   591 IQKD-QLLYNPFLKMCLSANGEHPS----------LVSCNPSDPLQKW 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	137/240 (57%)
		pp-GalNAc-T	153..457	CDD:133004	160/310 (52%)
		Ricin_B_lectin	516..658	CDD:279046	21/141 (15%)
		RICIN	524..660	CDD:238092	23/135 (17%)
GALNT3	NP_004473.2	Catalytic subdomain A	184..293		70/109 (64%)
		pp-GalNAc-T	188..493	CDD:133004	160/310 (52%)
		Catalytic subdomain B	356..418		41/61 (67%)
		Ricin_B_lectin	506..627	CDD:306998	32/199 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920