DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant3 and GALNT2

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	XP_016856452.1	Gene:	GALNT2 / 2590	HGNCID:	4124	Length:	636	Species:	Homo sapiens

Alignment Length:	499	Identity:	198/499 - (39%)
Similarity:	265/499 - (53%)	Gaps:	79/499 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LWLLYLFLLFFAFFMFAISINLYVASIQGG-------------------------DAEMRHPKPP 50
            |...:|::|..|::|::...:.......||                         .|:.....||
Human     9 LCFAFLWVLGIAYYMYSGGGSALAGGAGGGAGRKEDWNEIDPIKKKDLHHSNGEEKAQSMETLPP 73

  Fly    51 PKRRSLWPHKNIVAHYIGKGDIFGNMTADDYNINLFQPINGEGADGRPVVVPPRDRFRMQRFFRL 115
            .|.|  ||..|..| |:|     |.|..             .|.|       |..|
Human    74 GKVR--WPDFNQEA-YVG-----GTMVR-------------SGQD-------PYAR--------- 101

  Fly   116 NSFNLLASDRIPLNRTLKDYRTPECRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRH 180
            |.||.:.||::.::|.:.|.|..:|:.|::...||:|||:|.|||||.|.||||:.||:.:||.|
Human   102 NKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPH 166

  Fly   181 LLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFLDAH 245
            |:||||||||.|:.......|....||     |:.|..:|.||:.:|:.||:.|:..||||||:|
Human   167 LIKEIILVDDYSNDPEDGALLGKIEKV-----RVLRNDRREGLMRSRVRGADAAQAKVLTFLDSH 226

  Fly   246 CECSRGWLEPLLSRIKESRKVVICPVIDIISDDNFSYTKTFENHWGAFNWQLSFRW--FSSDRKR 308
            |||:..||||||.|:.|.|..|:.|:||:|:.|||.|.....:..|.|:|.|.|:|  .:.:::|
Human   227 CECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRR 291

  Fly   309 QTAGNSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEIS 373
            ...||    ...||.||.:|||||.:|:.||.|:|.||..|.||||||:|:|||:|||||.:||.
Human   292 SRQGN----PVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEII 352

  Fly   374 PCSHVGHVFRSSTPYTFPGGMSEVLTDNLARAATVWMDDWQYFIMLYTSGLTLGAKDKVNVTERV 438
            |||.||||||...|||||||...|...|..|||.||||:::.|  .|.:..:.......|:..|:
Human   353 PCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNF--YYAAVPSARNVPYGNIQSRL 415

  Fly   439 ALRERLQCKPFSWYLENIWPEHFFP-APDRFFGKIIWLDGETEC 481
            .||::|.||||.|||||::||...| ..|..||.   |...|.|
Human   416 ELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGA---LQQGTNC 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	122/237 (51%)
		pp-GalNAc-T	153..457	CDD:133004	152/305 (50%)
		Ricin_B_lectin	516..658	CDD:279046
		RICIN	524..660	CDD:238092
GALNT2	XP_016856452.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820