DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant3 and Galnt5

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_766443.2	Gene:	Galnt5 / 241391	MGIID:	2179403	Length:	930	Species:	Mus musculus

Alignment Length:	633	Identity:	216/633 - (34%)
Similarity:	321/633 - (50%)	Gaps:	140/633 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 HKNIV----AHYIGKGDIFGNMTADDYNINLFQPINGEGADGRPVVVPPRDRFRMQRFFRLNSFN 119
            |.||.    .|::.:.|:  .::..|        :|..|..||||||||..:...::.::..:||
Mouse   401 HANIPENPGMHHVFRIDV--TLSPRD--------LNAPGQFGRPVVVPPEKKKEAEQRWKEGNFN 455

  Fly   120 LLASDRIPLNRTLKDYRTPECRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKE 184
            :..||.||::|.::|.|...|.::...:.||:||:|:.|.:|.||.|||::.||:||||.||:||
Mouse   456 VYLSDLIPVDRAIEDTRPAGCAEQLVHNDLPTTSIIMCFVDEVWSALLRSVHSVLNRSPPHLIKE 520

  Fly   185 IILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFLDAHCECS 249
            |:||||.|.:.|||..|:.|:.... ..||.|:|:|.||:.|||.||:||.||||||||:|.||:
Mouse   521 ILLVDDFSTKEYLKADLDKYMSQFP-KVRILRLKERHGLIRARLAGAQNATGDVLTFLDSHVECN 584

  Fly   250 RGWLEPLLSRIKESRKVVICPVIDIISDDNFSYTKTFENHWGAFNWQLSFRWFSSDRKRQTAGNS 314
            .|||||||.|:..:||.|.||||::|:|.:.||........|.|.|.::|.| .:......|.|.
Mouse   585 VGWLEPLLERVYLNRKKVACPVIEVINDKDMSYMTVDNFQRGVFTWPMNFGW-KTIPPDVVAKNG 648

  Fly   315 SKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVG 379
            .|: ||.|..|.||||||:||:.||||:|:||..:.||||||:|:||::|.|||.:||.|||.||
Mouse   649 IKE-TDIIRCPVMAGGLFSIDKSYFYELGTYDPGLDVWGGENMELSFKVWMCGGEIEIIPCSRVG 712

  Fly   380 HVFRSSTPYTFPGGMSEVLTDNLARAATVWMDDWQYFIM-----LYTSGLTLGAKDKVNVTERVA 439
            |:||:..||:||....:.:..||.|.|.||:||::....     |...||.:|     |:|::..
Mouse   713 HIFRNDNPYSFPKDRMKTVERNLVRVAEVWLDDYRELFYGHGDHLIDQGLDVG-----NLTQQRE 772

  Fly   440 LRERLQCKPFSWYLENIWPEHFFPAPDRFFGKIIWLDGETECAQAYSKHMKNLPGRALSREWKRA 504
            ||::|:||.|.|||:|::|
Mouse   773 LRKKLKCKSFKWYLDNVFP---------------------------------------------- 791

  Fly   505 FEEIDSKAEELMA---LIDLERDKCLRPLKEDVPRSSLSAVTVGDCTSHAQSMDMFVITPKGQIM 566
                |.||..:.|   ||::...||:.  .|::      .||:.||...:| :..|..|
Mouse   792 ----DLKAPVVRASGVLINMALGKCVS--IENI------TVTLEDCDGSSQ-LQQFNYT------ 837

  Fly   567 TNDNVCLTYRQQKLGVIKMLKNRNATTSNVMLAQCASDSSQLWTYDMDTQQISHRDTKLCLTLKA 631
                           .::::|:.....:.:      .:...|..|..|     :|:.:|....|:
Mouse   838 ---------------WVRLIKHGEWCVAPI------PEKGSLTLYHCD-----NRNNRLKWLHKS 876

  Fly   632 ATNSRLQKVEKVV-------LSME------------CDFKDITQKWGF 660
            |:....:.|:.:|       |.||            |:..::.|||.|
Mouse   877 ASAFHPELVDHIVFENYQQLLCMEGNFSQKTLKLAACNPMELQQKWKF 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	126/235 (54%)
		pp-GalNAc-T	153..457	CDD:133004	152/308 (49%)
		Ricin_B_lectin	516..658	CDD:279046	28/163 (17%)
		RICIN	524..660	CDD:238092	27/154 (18%)
Galnt5	NP_766443.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..209
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..381
		Catalytic subdomain A	485..594		65/109 (60%)
		pp-GalNAc-T	489..790	CDD:133004	152/308 (49%)
		Catalytic subdomain B	654..716		38/61 (62%)
		RICIN	805..925	CDD:214672	29/161 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810