DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant3 and Galnt18

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_776100.2	Gene:	Galnt18 / 233733	MGIID:	2446239	Length:	622	Species:	Mus musculus

Alignment Length:	690	Identity:	208/690 - (30%)
Similarity:	303/690 - (43%)	Gaps:	184/690 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 YVASIQGGDAEMRHPKPPPKRRSLWPHKNIVAHYIGKGDIFGNMTADDYNINLFQ------PING 91
            |:||:.     :|..:|.|.::.          ...|||....:...|:..|:.:      |...
Mouse    35 YIASVY-----VRGQEPVPDKKL----------EEDKGDTLKIIERLDHLENVIKQHIQEAPAKP 84

  Fly    92 EGADGRPVV-----------VPPRDRFRMQRFFRLNSFNLLASDRIPLNRTLKDYRTPECRDKKY 145
            |.|:..|..           :.|..|....:.|:...:|...|||:||:|.|.|.|...||:..:
Mouse    85 EEAEAEPFTDSSLFAHWGQELSPEGRRVALKQFQYYGYNAYLSDRLPLDRPLPDLRPSGCRNLSF 149

  Fly   146 ASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLESYV-KVLA 209
            ...||..|::.:|.|||.|||||:|.|.:.|:|.|||||||||||.|....||.:|..|| ||..
Mouse   150 PDSLPEVSIVFIFVNEALSVLLRSIHSAMERTPSHLLKEIILVDDNSSNEELKEKLTEYVDKVNG 214

  Fly   210 VP---TRIFRMKKRSGLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVICPV 271
            ..   .::.|..|:.||:.:|:.|...|...|:...|||.|.:.||.||:|:||||:||.:|.|.
Mouse   215 QKPGFIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHVEFNVGWAEPVLTRIKENRKRIISPS 279

  Fly   272 IDIISDDNF---SYTKTFENHWGAFNWQLSFRWFSSDRKRQTAGNSSKDSTDPIATPGMAGGLFA 333
            .|.|..|||   .|....:    .|:|:|..|:.:..:    |....::||.||.:|.:. |.|.
Mouse   280 FDNIKYDNFEIEEYPLAAQ----GFDWELWCRYLNPPK----AWWKLENSTAPIRSPALI-GCFI 335

  Fly   334 IDRKYFYEMGSYDSNMRVWGGENVEMSFR---------------IWQCGGRVEISPCSHVGHVFR 383
            :||:||.|:|..|..|.|:||||||:..|               :|||||.||:.|||.:.|:.|
Mouse   336 VDRQYFEEIGLLDEGMEVYGGENVELGIRVSEISHTGLSSAPMMVWQCGGSVEVLPCSRIAHIER 400

  Fly   384 SSTPYTFPGGMSEVLT----DNLARAATVWMDDWQYFIML------YTSGLTLGAKDKVNVTERV 438
            :..|||      |.||    .|..|.|.||||:::..:.:      ..||:.:|     ::|.|.
Mouse   401 AHKPYT------EDLTAHVRRNALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIG-----DITARK 454

  Fly   439 ALRERLQCKPFSWYLENIWPEHFFPAPDRFFGKIIWLDGETECAQAYSKHMKNLPGRALSREWKR 503
            |||::||||.|.|||.:::||.      |.:..||          ||.. ::|
Mouse   455 ALRKQLQCKTFRWYLVSVYPEM------RMYSDII----------AYGV-LQN------------ 490

  Fly   504 AFEEIDSKAEELMALIDLERDKCL--RPLKEDVPRSSLSAVTVGDC----------TSHAQSMDM 556
                            .|:.|.||  .|..|:||       .|..|          || :|.:.:
Mouse   491 ----------------SLKTDLCLDQGPDTENVP-------IVYICHGMTPQNVYYTS-SQQIHV 531

  Fly   557 FVITPKGQIMTNDNVCLTYRQQKLGVIKMLKNRNATTSNVMLAQCASDSSQL----WTYDMDTQQ 617
            .:::|  .:..:||.||.                ...|...|.:|:...::.    |.:... ..
Mouse   532 GILSP--TVDDDDNRCLV----------------DVNSRPRLIECSYAKAKRMKLHWQFSQG-GS 577

  Fly   618 ISHRDTKLCLTLKAATNSRLQKVEKVVLSMECDFKDITQK 657
            |.:|.:|.||.|:  .||          .||..|:.:.||
Mouse   578 IQNRKSKRCLELQ--ENS----------DMEFGFQLVLQK 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	105/257 (41%)
		pp-GalNAc-T	153..457	CDD:133004	133/335 (40%)
		Ricin_B_lectin	516..658	CDD:279046	35/158 (22%)
		RICIN	524..660	CDD:238092	34/150 (23%)
Galnt18	NP_776100.2	Catalytic subdomain A	153..267		52/113 (46%)
		pp-GalNAc-T	157..473	CDD:133004	133/335 (40%)
		Catalytic subdomain B	324..400		32/76 (42%)
		Ricin_B_lectin	484..611	CDD:279046	38/190 (20%)
		RICIN	486..613	CDD:238092	36/188 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810