DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant3 and Galnt11

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001346819.1	Gene:	Galnt11 / 231050	MGIID:	2444392	Length:	608	Species:	Mus musculus

Alignment Length:	618	Identity:	213/618 - (34%)
Similarity:	329/618 - (53%)	Gaps:	73/618 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 WLLYLFLLFFAFFMFA-ISINLYVASIQGGDAEMRHPKPPPKRRSLWPHKNIVAHY-IGKGDIFG 74
            |.:.||:    :|.|: ::..|....|:|.......||....|.:..|.:.:...: ..:.|...
Mouse    20 WTVLLFI----YFNFSEVTQPLRNVPIKGSGPHGPFPKKFYPRFTRGPGRVLDPQFKANRIDRLM 80

  Fly    75 NMTADDYNINLFQPINGEGADGRPVVVPPRDRFRMQRFFRLNSFNLLASDRIPLNRTLKDYRTPE 139
            |...:|.:..|.:..:..|     ::...||:......::.::||:|.|:|:..:|.:.|.|..|
Mouse    81 NNHIEDPDKGLSKSSSELG-----MIFNERDQELRDLGYQKHAFNMLISNRLGYHRDVPDTRNAE 140

  Fly   140 CRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLESY 204
            ||.|.|.:.||:.|::|.|:|||:|.||||:.||::|:|.|||.|||||||:||...||.:|:.|
Mouse   141 CRRKSYPTDLPTASIVICFYNEAFSALLRTVHSVVDRTPAHLLHEIILVDDSSDFDDLKGELDEY 205

  Fly   205 V-KVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVI 268
            : :.|....::.|..||.||:..|::||.:|.|:||.|||:|||.:..||:|||:.|.|....|:
Mouse   206 IQRYLPAKVKVIRNMKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAIILEDPHTVV 270

  Fly   269 CPVIDIISDDNFSYTKTFENHWGAFNWQLSFRWFSSDRKRQTAGNSSKDSTDPIATPGMAGGLFA 333
            ||||||||.|..:|:.:.... |.|||.|.|:|   |....:.......:|.||.:|.|||||||
Mouse   271 CPVIDIISADTLAYSSSPVVR-GGFNWGLHFKW---DLVPVSELGGPDGATAPIRSPTMAGGLFA 331

  Fly   334 IDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVL 398
            ::|:||.::|.|||.|.:|||||:|:|||||.|||::.|.|||.|||:||...||..|.| .:.:
Mouse   332 MNRQYFNDLGQYDSGMDIWGGENLEISFRIWMCGGKLFILPCSRVGHIFRKRRPYGSPEG-QDTM 395

  Fly   399 TDNLARAATVWMDDW--QYFIMLYTSGLTLGAKDKV--NVTERVALRERLQCKPFSWYLENIWPE 459
            |.|..|.|.||:|::  |||      .|....|:|.  |::|||.||::|.|:.|.|||:||:||
Mouse   396 THNSLRLAHVWLDEYKEQYF------SLRPDLKNKSFGNISERVELRKKLGCQSFKWYLDNIYPE 454

  Fly   460 HFFPAPDRFFGKIIWLDGETECAQAYSKHMKNLPGRALSREWKRAFEEIDSKAEELMALIDLERD 524
            ...|.|:                   :|..:.:   .::|..||      .:..:...|..|:.:
Mouse   455 MQIPGPN-------------------AKPQQPV---LINRGPKR------PRVLQRGRLYHLQTN 491

  Fly   525 KCLRPLKEDVPRSSLSAVTVGDCTSHAQSMDMFVITPKGQIMTNDNVCLTYRQQKLGVIKMLKNR 589
            |||........:..|  |.:..| .:.....:::.....:::.|:.:||          .|.:.|
Mouse   492 KCLVAQGRSSQKGGL--VLLKTC-DYGDPTQVWIYNEDHELILNNLLCL----------DMSETR 543

  Fly   590 NATTSNVMLAQC-ASDSSQLWTYDMDTQ--QIS 619
            ::....:|  :| .|..||.||:..:.:  |:|
Mouse   544 SSDPPRLM--KCHGSGGSQQWTFGKNNRLYQVS 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	119/236 (50%)
		pp-GalNAc-T	153..457	CDD:133004	148/308 (48%)
		Ricin_B_lectin	516..658	CDD:279046	22/107 (21%)
		RICIN	524..660	CDD:238092	20/99 (20%)
Galnt11	NP_001346819.1	Catalytic subdomain A	150..261		57/110 (52%)
		pp-GalNAc-T	154..452	CDD:133004	148/308 (48%)
		Catalytic subdomain B	319..381		39/61 (64%)
		Ricin_B_lectin	483..604	CDD:306998	22/107 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820