Protein Alignment Pgant3 and Galnt6

DIOPT Version :10

• Sequence 1: NP_610256.1
• Gene: Pgant3 / 35627
• FlyBaseID: FBgn0027558
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_766039.2
• Gene: Galnt6 / 207839
• MGIID: 1891640
• Length: 622
• Species: Mus musculus
• Alignment Length: 690
• Identity: 245/690 - (35%)
• Similarity: 338/690 - (48%)
• Gaps: 156/690 - (22%)

  Fly     1 MGLRFQQLKKLWLLYLFL-------------------------LFFAFFMFAI-SINLYVASIQG 39
            |.||...|..:::|:||:                         ....|.:.|: :|...:..:|
Mouse     9 MSLRLAMLGSVFMLFLFIRQKDVSNQEQAMEKPWLKSLAGQKDQVLDFMLGAVNNIRDVMPKLQ- 72

  Fly    40 GDAEMRHPKPPPKRRSLWPHKNIVAHYIGKGDIFGNMTADDYNINLF-----QPINGEGADGRPV 99
                :|.|:||....|. .|..:...|            ....:..|     |..|..||||:
Mouse    73 ----IRAPEPPQTLVST-NHSCLPGFY------------TPAELKPFWDRPPQDPNSPGADGK-- 118

  Fly   100 VVPPRDRFRMQRF-----------FRLNSFNLLASDRIPLNRTL-KDYRTPECRDKKY--ASGLP 150
                  .|:.:.:           ::.:.||..|||||.|.|:| .|.|.|||.|:|:  ...||
Mouse   119 ------AFQKKEWTNLETKEKEEGYKKHCFNAFASDRISLQRSLGPDTRPPECVDQKFRRCPPLP 177

  Fly   151 STSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIF 215
            :|||||||||||||.||||:.||::.||..||||||||||||...:||.:||.||:.|.: .|:.
Mouse   178 TTSVIIVFHNEAWSTLLRTVYSVLHTSPAILLKEIILVDDASTDEHLKERLEQYVQQLQI-VRVV 241

  Fly   216 RMKKRSGLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVICPVIDIISDDNF 280
            |.::|.||:.||||||..|:.:|||||||||||..|||||||:||.|.:..|:.|.|..|..:.|
Mouse   242 RQRERKGLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTAVVSPDIVTIDLNTF 306

  Fly   281 SYTKTFE----NHWGAFNWQLSFRW-FSSDRKRQTAGNSSKDSTDPIATPGMAGGLFAIDRKYFY 340
            .:::..:    :..|.|:|.|:|.| ...:.::|    ..||.|.||.:|..|||||:|.:.||.
Mouse   307 QFSRPVQRGKAHSRGNFDWSLTFGWEMLPEHEKQ----RRKDETYPIKSPTFAGGLFSISKAYFE 367

  Fly   341 EMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNLARA 405
            .:|:||:.|.:|||||||||||:|||||::||.|||.||||||:.:|:|||.|.| |:..|..|.
Mouse   368 HIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKGTS-VIARNQVRL 431

  Fly   406 ATVWMDDWQYFIMLYTSGLTLGAKDKVN----VTERVALRERLQCKPFSWYLENIWPEHFFP-AP 465
            |.|||||  |..:.|...|......:.|    ::||:.|||:|:|..|||||.|::||.|.| ..
Mouse   432 AEVWMDD--YKKIFYRRNLQAAKMVQENNFGDISERLRLREQLRCHNFSWYLHNVYPEMFVPDLN 494

  Fly   466 DRFFGKIIWLDGETECAQA------------YSKHMKNLPGRALSREWKRAFEEIDSKAEELMAL 518
            ..|:|.|..| |..:|...            |..|  ||.|       .:.||....:
Mouse   495 PTFYGAIKNL-GTNQCLDVGENNRGGKPLIMYVCH--NLGG-------NQYFEYTSQR------- 542

  Fly   519 IDLE----RDKCLRPLKEDVPRSSLSAVTVGDC-----TSHAQSMDMFVITPKGQIMTN--DNVC 572
             ||.    :..||        .:|.|.:.:..|     .|.....:.:.:| :.|::.|  ...|
Mouse   543 -DLRHNIGKQLCL--------HASGSTLGLRSCQFVGKNSRVPKDEEWELT-QDQLIRNSGSGTC 597

  Fly   573 LTYRQQKLGVIKMLKNRNATTSNVMLAQC-ASDSSQLWTY 611
            ||.:.:|                ..:|.| ..|..|||.:
Mouse   598 LTSQDKK----------------PAMAPCNPRDPYQLWLF 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	pp-GalNAc-T	153..457	CDD:133004	161/312 (52%)
		beta-trefoil_Ricin_Pgant3-like	515..661	CDD:467338	21/109 (19%)
Galnt6	NP_766039.2	Catalytic subdomain A	176..285		72/109 (66%)
		pp-GalNAc-T	180..485	CDD:133004	161/312 (52%)
		Catalytic subdomain B	348..410		40/61 (66%)
		beta-trefoil_Ricin-like	495..622	CDD:483949	34/170 (20%)