DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant3 and Galnt6

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001155239.1	Gene:	Galnt6 / 207839	MGIID:	1891640	Length:	622	Species:	Mus musculus

Alignment Length:	690	Identity:	245/690 - (35%)
Similarity:	338/690 - (48%)	Gaps:	156/690 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGLRFQQLKKLWLLYLFL-------------------------LFFAFFMFAI-SINLYVASIQG 39
            |.||...|..:::|:||:                         ....|.:.|: :|...:..:|
Mouse     9 MSLRLAMLGSVFMLFLFIRQKDVSNQEQAMEKPWLKSLAGQKDQVLDFMLGAVNNIRDVMPKLQ- 72

  Fly    40 GDAEMRHPKPPPKRRSLWPHKNIVAHYIGKGDIFGNMTADDYNINLF-----QPINGEGADGRPV 99
                :|.|:||....|. .|..:...|            ....:..|     |..|..||||:
Mouse    73 ----IRAPEPPQTLVST-NHSCLPGFY------------TPAELKPFWDRPPQDPNSPGADGK-- 118

  Fly   100 VVPPRDRFRMQRF-----------FRLNSFNLLASDRIPLNRTL-KDYRTPECRDKKY--ASGLP 150
                  .|:.:.:           ::.:.||..|||||.|.|:| .|.|.|||.|:|:  ...||
Mouse   119 ------AFQKKEWTNLETKEKEEGYKKHCFNAFASDRISLQRSLGPDTRPPECVDQKFRRCPPLP 177

  Fly   151 STSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIF 215
            :|||||||||||||.||||:.||::.||..||||||||||||...:||.:||.||:.|.: .|:.
Mouse   178 TTSVIIVFHNEAWSTLLRTVYSVLHTSPAILLKEIILVDDASTDEHLKERLEQYVQQLQI-VRVV 241

  Fly   216 RMKKRSGLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVICPVIDIISDDNF 280
            |.::|.||:.||||||..|:.:|||||||||||..|||||||:||.|.:..|:.|.|..|..:.|
Mouse   242 RQRERKGLITARLLGASVAQAEVLTFLDAHCECFHGWLEPLLARIAEDKTAVVSPDIVTIDLNTF 306

  Fly   281 SYTKTFE----NHWGAFNWQLSFRW-FSSDRKRQTAGNSSKDSTDPIATPGMAGGLFAIDRKYFY 340
            .:::..:    :..|.|:|.|:|.| ...:.::|    ..||.|.||.:|..|||||:|.:.||.
Mouse   307 QFSRPVQRGKAHSRGNFDWSLTFGWEMLPEHEKQ----RRKDETYPIKSPTFAGGLFSISKAYFE 367

  Fly   341 EMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNLARA 405
            .:|:||:.|.:|||||||||||:|||||::||.|||.||||||:.:|:|||.|.| |:..|..|.
Mouse   368 HIGTYDNQMEIWGGENVEMSFRVWQCGGQLEIIPCSVVGHVFRTKSPHTFPKGTS-VIARNQVRL 431

  Fly   406 ATVWMDDWQYFIMLYTSGLTLGAKDKVN----VTERVALRERLQCKPFSWYLENIWPEHFFP-AP 465
            |.|||||  |..:.|...|......:.|    ::||:.|||:|:|..|||||.|::||.|.| ..
Mouse   432 AEVWMDD--YKKIFYRRNLQAAKMVQENNFGDISERLRLREQLRCHNFSWYLHNVYPEMFVPDLN 494

  Fly   466 DRFFGKIIWLDGETECAQA------------YSKHMKNLPGRALSREWKRAFEEIDSKAEELMAL 518
            ..|:|.|..| |..:|...            |..|  ||.|       .:.||....:
Mouse   495 PTFYGAIKNL-GTNQCLDVGENNRGGKPLIMYVCH--NLGG-------NQYFEYTSQR------- 542

  Fly   519 IDLE----RDKCLRPLKEDVPRSSLSAVTVGDC-----TSHAQSMDMFVITPKGQIMTN--DNVC 572
             ||.    :..||        .:|.|.:.:..|     .|.....:.:.:| :.|::.|  ...|
Mouse   543 -DLRHNIGKQLCL--------HASGSTLGLRSCQFVGKNSRVPKDEEWELT-QDQLIRNSGSGTC 597

  Fly   573 LTYRQQKLGVIKMLKNRNATTSNVMLAQC-ASDSSQLWTY 611
            ||.:.:|                ..:|.| ..|..|||.:
Mouse   598 LTSQDKK----------------PAMAPCNPRDPYQLWLF 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	131/240 (55%)
		pp-GalNAc-T	153..457	CDD:133004	161/312 (52%)
		Ricin_B_lectin	516..658	CDD:279046	21/108 (19%)
		RICIN	524..660	CDD:238092	19/96 (20%)
Galnt6	NP_001155239.1	Catalytic subdomain A	176..285		72/109 (66%)
		pp-GalNAc-T	180..485	CDD:133004	161/312 (52%)
		Catalytic subdomain B	348..410		40/61 (66%)
		Ricin_B_lectin	497..619	CDD:366226	32/164 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920