DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant3 and gly-5

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001379253.1	Gene:	gly-5 / 176736	WormBaseID:	WBGene00001630	Length:	626	Species:	Caenorhabditis elegans

Alignment Length:	690	Identity:	241/690 - (34%)
Similarity:	341/690 - (49%)	Gaps:	127/690 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LKKLWLLYLFLLFFAFFMFAISINLYVASIQGGDAEMR--------HPKP----------PPKRR 54
            ||.|.|:.:|.:....|..|.|.:   :|..|.:.::.        |||.          ||...
Worm    10 LKVLLLVPVFWICSLIFFAATSND---SSQIGSNNDLANKIAEANFHPKAAKQDVIQGFGPPIEP 71

  Fly    55 SLWPHKNIVAHYIGKGDIFGNMTADDYNINLFQPI--NGEGAD----GRPVVV-----PPRDRFR 108
            ......|.|......|   ||:....:.::...||  .|:.|.    |:.|||     ...::.:
Worm    72 EPVVENNKVEEEEQPG---GNLAKPKFMVDPNDPIYKKGDAAQAGELGKAVVVDKTKLSTEEKAK 133

  Fly   109 MQRFFRLNSFNLLASDRIPLNRTLKDYRTPECRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSV 173
            ..:....|:||..|||.|.::|||......||:.:||...||.|||||.||||||||||||:.||
Worm   134 YDKGMLNNAFNQYASDMISVHRTLPTNIDAECKTEKYNENLPRTSVIICFHNEAWSVLLRTVHSV 198

  Fly   174 INRSPRHLLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRSGLVPARLLGAENARGDV 238
            :.|:|.|||:|::||||.||..:.||.||.|:.......:|.||:||.||:.|||.||..|.|:|
Worm   199 LERTPDHLLEEVVLVDDFSDMDHTKRPLEEYMSQFGGKVKILRMEKREGLIRARLRGAAVATGEV 263

  Fly   239 LTFLDAHCECSRGWLEPLLSRIKESRKVVICPVIDIISDDNFSY--TKTFENHWGAFNWQLSFRW 301
            ||:||:||||..||:||||.|||.....|:|||||:|.|:.|.|  :|.:....|.|:|.|.|.|
Worm   264 LTYLDSHCECMEGWMEPLLDRIKRDPTTVVCPVIDVIDDNTFEYHHSKAYFTSVGGFDWGLQFNW 328

  Fly   302 FS---SDRKRQTAGNSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRI 363
            .|   .|||.:|.      ..||:.:|.||||||:||:|||.::|:||....:|||||:|:||:|
Worm   329 HSIPERDRKNRTR------PIDPVRSPTMAGGLFSIDKKYFEKLGTYDPGFDIWGGENLELSFKI 387

  Fly   364 WQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNLARAATVWMDDWQYFIMLYTSGLTLGA 428
            |.|||.:||.||||||||||..:||.:..|:: ||..|..|.|.||:||::.:   |...:....
Worm   388 WMCGGTLEIVPCSHVGHVFRKRSPYKWRTGVN-VLKRNSIRLAEVWLDDYKTY---YYERINNQL 448

  Fly   429 KDKVNVTERVALRERLQCKPFSWYLENIWPEHFFPAPDRFFGKIIWLDGETECAQAYSKHMKNLP 493
            .|..:::.|..|||.|.||.|.|||:||:||.|                              :|
Worm   449 GDFGDISSRKKLREDLGCKSFKWYLDNIYPELF------------------------------VP 483

  Fly   494 GRALSREWKRAFEEIDSKAEELMALID--LERDKCLRPLKEDVPRSSLSAVTVGDCTSHAQSMDM 556
            |.::::      .|:.:.|.:....:|  :.|.:..||              ||....|.|..:.
Worm   484 GESVAK------GEVRNSAVQPARCLDCMVGRHEKNRP--------------VGTYQCHGQGGNQ 528

  Fly   557 FVITPKGQIMTNDNVCLTYRQQKLGVIKMLKNRNATTSNVMLAQC-ASDSSQLWTYDMDTQQISH 620
            :.:..|...:..|..|:.|                ..|:||:..| ....:|.|.|:.||.::.|
Worm   529 YWMLSKDGEIRRDESCVDY----------------AGSDVMVFPCHGMKGNQEWRYNHDTGRLQH 577

  Fly   621 RDTKLCLTLKAATNSRLQKVEKVVLSMECDFKDITQKWGF 660
            ..::.||.: ....::|:.|       .|.:.|..|.|.|
Worm   578 AVSQKCLGM-TKDGAKLEMV-------ACQYDDPYQHWKF 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	133/240 (55%)
		pp-GalNAc-T	153..457	CDD:133004	157/308 (51%)
		Ricin_B_lectin	516..658	CDD:279046	29/144 (20%)
		RICIN	524..660	CDD:238092	28/136 (21%)
gly-5	NP_001379253.1	pp-GalNAc-T	178..477	CDD:133004	157/308 (51%)
gly-5	NP_001379253.1	Ricin_B_lectin	488..607	CDD:395527	31/162 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920