DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant3 and gly-3

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_498722.1	Gene:	gly-3 / 176112	WormBaseID:	WBGene00001628	Length:	612	Species:	Caenorhabditis elegans

Alignment Length:	626	Identity:	245/626 - (39%)
Similarity:	338/626 - (53%)	Gaps:	107/626 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 HPKPPPKR-RSLWPHKNIVAHYIGK---GDIFGNMTADDYNINLFQPINGEGADGRPVVVPPRDR 106
            ||..|.|: :.::|.....|:.:.|   ...||            ...:|:|..|  |.||...:
Worm    73 HPIQPEKQEKQVYPVDKETANQLRKLMETQAFG------------PGYHGQGGTG--VTVPEDKK 123

  Fly   107 FRMQRFFRLNSFNLLASDRIPLNRTLKDYRTPECR---DKKYASGLPSTSVIIVFHNEAWSVLLR 168
            ...::.|..|.||::||:.|.:||||.|||:..||   :....:|:|.||:|||||||||:.|||
Worm   124 TIKEKRFLENQFNVVASEMISVNRTLPDYRSDACRTSGNNLKTAGMPKTSIIIVFHNEAWTTLLR 188

  Fly   169 TITSVINRSPRHLLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRSGLVPARLLGAEN 233
            |:.|||||||||||:|||||||.|||.||.:.|:||:|:..:|..:..::.||||:.|||.|:|.
Worm   189 TLHSVINRSPRHLLEEIILVDDKSDRDYLVKPLDSYIKMFPIPIHLVHLENRSGLIRARLTGSEM 253

  Fly   234 ARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVICPVIDIISDDNFSYTKTFENHWGAFNWQLS 298
            |:|.:|.|||||.|.:.||||||:||:.|.||.|:.|:||:||||.|.|....|..||.|||.|:
Worm   254 AKGKILLFLDAHVEVTDGWLEPLVSRVAEDRKRVVAPIIDVISDDTFEYVTASETTWGGFNWHLN 318

  Fly   299 FRWFSSDRKRQTAGNSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRI 363
            |||::..::......|  |.:.||.||.:||||||||:::||::||||..|:||||||:|:|||:
Worm   319 FRWYAVPKRELNRRGS--DRSMPIQTPTIAGGLFAIDKQFFYDIGSYDEGMQVWGGENLEISFRV 381

  Fly   364 WQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNLARAATVWMDDWQ-YFIMLYTSGLTLG 427
            |.|||.:||.|||.||||||..||||||||.::|:..|.||.|.||||::: :|..:..:...:.
Worm   382 WMCGGSLEIHPCSRVGHVFRKQTPYTFPGGTAKVIHHNAARTAEVWMDEYKAFFYKMVPAARNVE 446

  Fly   428 AKDKVNVTERVALRERLQCKPFSWYLENIWPEHFFPAPDRFFGKIIWLDGETE-CAQAYSKHMKN 491
            |.|   |:||..|||.||||.|.||||||:||...||..|..|.|:  :..|| |.....|....
Worm   447 AGD---VSERKKLRETLQCKSFKWYLENIYPEAPLPADFRSLGAIV--NRFTEKCVDTNGKKDGQ 506

  Fly   492 LPGRALSREWKRAFEEIDSKAEELMALIDLERDKCLRPLKEDVPRSSLSAVTVGDCTSHAQSMDM 556
            .||                                                 :..|.. |.....
Worm   507 APG-------------------------------------------------IQACHG-AGGNQA 521

  Fly   557 FVITPKGQIMTNDNVCLTY-RQQKLGVIKMLKNRNATTSNVMLAQCASDS---SQLWTYDMDTQQ 617
            :.:|.||:| .:|::||:. ...::|            |.:.|.:|:...   ..::.:|.....
Worm   522 WSLTGKGEI-RSDDLCLSSGHVYQIG------------SELKLERCSVSKINVKHVFVFDDQAGT 573

  Fly   618 ISHRDTKLCLTLKAATNSRLQKVEKVVLSMECDFKDITQKW 658
            :.|:.|..|:|         ...::|.|. ||......|.|
Worm   574 LLHKKTGKCVT---------GADQRVTLD-ECGLGRKDQMW 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	139/235 (59%)
		pp-GalNAc-T	153..457	CDD:133004	173/304 (57%)
		Ricin_B_lectin	516..658	CDD:279046	23/145 (16%)
		RICIN	524..660	CDD:238092	24/139 (17%)
gly-3	NP_498722.1	pp-GalNAc-T	173..473	CDD:133004	173/304 (57%)
		Glyco_tranf_2_2	173..438	CDD:287123	155/266 (58%)
		Ricin_B_lectin	486..604	CDD:279046	31/192 (16%)
		RICIN	486..604	CDD:238092	31/192 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2642
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194016at33208
OrthoFinder	1	1.000	-	-		FOG0002015
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.870