DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant3 and gly-6

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001022644.1	Gene:	gly-6 / 175558	WormBaseID:	WBGene00001631	Length:	618	Species:	Caenorhabditis elegans

Alignment Length:	662	Identity:	257/662 - (38%)
Similarity:	365/662 - (55%)	Gaps:	80/662 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LYLFLLFFAFFMFAISINLYVASIQGGDAEMRHPKP-PPKRRSLWPHKNIVAHYIGK--GDIFGN 75
            |:.||..:..|..|:   ::::.:..|:.::...|. .|..||  .:..:|.||.|.  .|...|
Worm    22 LFGFLALWGSFALAL---VFLSDMYIGEDQISTQKAIKPIARS--NYHVVVGHYNGNLPEDKKRN 81

  Fly    76 MTADDYNINLFQPIN--GEGADGRPVVVPPRDRFRMQRFFRLNSFNLLASDRIPLNRTLKDYRTP 138
            :|:::.|.||:.|.:  |||..|...:.|.:.:. ....|.:|.||||.||.|.:.|:|.:.|.|
Worm    82 LTSEELNANLYAPHDDWGEGGAGVSHLTPEQQKL-ADSTFAVNQFNLLVSDGISVRRSLPEIRKP 145

  Fly   139 ECRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLK-RQLE 202
            .||:..|...||:||||||:||||:|.||||:.|||:|||:.||||||||||.|||.:|: ..|:
Worm   146 SCRNMTYPDNLPTTSVIIVYHNEAYSTLLRTVWSVIDRSPKELLKEIILVDDFSDREFLRYPTLD 210

  Fly   203 SYVKVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVV 267
            :.:|.|....:|.|.|:|.||:.||::||:.|:||||||||:||||::|||||||:|||.:||.|
Worm   211 TTLKPLPTDIKIIRSKERVGLIRARMMGAQEAQGDVLTFLDSHCECTKGWLEPLLTRIKLNRKAV 275

  Fly   268 ICPVIDIISDDNFSYTKTFENHWGAFNWQLSFRWFSSDRKRQTAGNSSKDSTDPIATPGMAGGLF 332
            .|||||||:|:.|.|.|..|...|.|||.|.|||:.  .....|.....|.|.||.:|.||||||
Worm   276 PCPVIDIINDNTFQYQKGIEMFRGGFNWNLQFRWYG--MPTAMAKQHLLDPTGPIESPTMAGGLF 338

  Fly   333 AIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMS-E 396
            :|:|.||.|:|.||..|.:|||||:|||||||||||||||.||||||||||.|:|:.|||..| :
Worm   339 SINRNYFEELGEYDPGMDIWGGENLEMSFRIWQCGGRVEILPCSHVGHVFRKSSPHDFPGKSSGK 403

  Fly   397 VLTDNLARAATVWMDDWQ-YFIMLYTSGLTLGAKDKVNVTERVALRERLQCKPFSWYLENIWPEH 460
            ||..||.|.|.||||||: ||..:......:  :..::|:|||.||::|.||.|.|||:|::.:|
Worm   404 VLNTNLLRVAEVWMDDWKHYFYKIAPQAHRM--RSSIDVSERVELRKKLNCKSFKWYLQNVFQDH 466

  Fly   461 FFPAPDRFFGKIIWLDGETECAQAYSKHMKNLPGRALSREWKRAFEEIDSKAEELMALIDLERDK 525
            |.|.|...||::......:.|
Worm   467 FLPTPLDRFGRMTSSSNSSVC-------------------------------------------- 487

  Fly   526 CLRPLKEDVPRSSLSAVTVGDCTSHAQSMDMFVITPKGQIMTNDNVCLTYRQQKLGVIKMLKNRN 590
                |...:..|.:...:..||........:::.|...:|.|::::||:       |:::|.
Worm   488 ----LAWTLRSSGIKTASTADCLKIFHKTQLWLYTGDRRIRTDEHLCLS-------VVQLLH--- 538

  Fly   591 ATTSN--VMLAQCASDSSQLWTYDMDTQQISHRDTKLCLTLKAATNSRLQKVEKVVLSMECDFKD 653
             |||:  :.|.:||...::.|.:.....:..:|.|.|||......:....:....:: .:|...:
Worm   539 -TTSDWKIQLKECAGFDTEYWDFKPKIGRFQNRKTGLCLASPDIFDPTKDEFNPPIV-QKCRSSN 601

  Fly   654 ITQKWGFIPLPW 665
            ..|.|....:.|
Worm   602 DRQNWTITEMSW 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	146/236 (62%)
		pp-GalNAc-T	153..457	CDD:133004	178/306 (58%)
		Ricin_B_lectin	516..658	CDD:279046	25/143 (17%)
		RICIN	524..660	CDD:238092	26/137 (19%)
gly-6	NP_001022644.1	WcaA	155..451	CDD:223539	173/299 (58%)
		pp-GalNAc-T	160..463	CDD:133004	178/306 (58%)
		Ricin_B_lectin	474..606	CDD:279046	28/191 (15%)
		RICIN	476..608	CDD:238092	28/191 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I7030
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18268
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194016at33208
OrthoFinder	1	1.000	-	-		FOG0002015
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_119244
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.920