DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant3 and GALNTL5

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	XP_016867282.1	Gene:	GALNTL5 / 168391	HGNCID:	21725	Length:	496	Species:	Homo sapiens

Alignment Length:	483	Identity:	174/483 - (36%)
Similarity:	254/483 - (52%)	Gaps:	77/483 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 QGGDAEMRHPKPPPKRRSL------WPHKN---IVAHYIGKGDIFGNMTADDYNINLF------- 86
            :||.:..:|  ..|.||.|      |..:|   .:.:.|.:|..:|::|...:...||
Human    22 EGGVSVAQH--SIPCRRHLVQEIEKWTFENARFTMRNAIIQGLFYGSLTFGIWTALLFIYLHHNH 84

  Fly    87 ---------QPING------------EGADGRP---VVVPPRDRFRMQR-----FFRLN------ 116
                     :|::.            .|::..|   |:|...|..:.:.     |...|
Human    85 VSSWQKKSQEPLSAWSPGKKVHQQIIYGSEQIPKPHVIVKRTDEDKAKSMLGTDFNHTNPELHKE 149

  Fly   117 ----SFNLLASDRIPLNRTLKDYRTPECRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRS 177
                .||::.|..:.:.|.:.|.|:..|..|.|.:.||:.|::|.|:||..:.|.:|::||.|.:
Human   150 LLKYGFNVIISRSLGIEREVPDTRSKMCLQKHYPARLPTASIVICFYNEECNALFQTMSSVTNLT 214

  Fly   178 PRHLLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFL 242
            |.:.|:|||||||.|....||.:|:.:::......:|.|.|||.||:.|||:||.:|.||||.||
Human   215 PHYFLEEIILVDDMSKVDDLKEKLDYHLETFRGKVKIIRNKKREGLIRARLIGASHASGDVLVFL 279

  Fly   243 DAHCECSRGWLEPLLSRIKESRKVVICPVIDIISDDNFSYTKTFENHWGAFNWQLSFRW---FSS 304
            |:|||.:|.||||||..|.:..|:|:||:||:|.|....| |......|.|:|.|.|:|   ||.
Human   280 DSHCEVNRVWLEPLLHAIAKDPKMVVCPLIDVIDDRTLEY-KPSPLVRGTFDWNLQFKWDNVFSY 343

  Fly   305 DRKRQTAGNSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGR 369
            :.      :..:.||.||.:|.|:||:|||.|.||.|:|.||.:|..||.||:|:|.|||.|||:
Human   344 EM------DGPEGSTKPIRSPAMSGGIFAIRRHYFNEIGQYDKDMDFWGRENLELSLRIWMCGGQ 402

  Fly   370 VEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNLARAATVWMDDWQYFIMLYTSGL---TLGAKDK 431
            :.|.|||.|||:.:..|..  |..:...:|.|..|...||:|:::....|...||   |.|
Human   403 LFIIPCSRVGHISKKQTGK--PSTIISAMTHNYLRLVHVWLDEYKEQFFLRKPGLKYVTYG---- 461

  Fly   432 VNVTERVALRERLQCKPFSWYLENIWPE 459
             |:.|||.||:||.||.|.|||:|::||
Human   462 -NIRERVELRKRLGCKSFQWYLDNVFPE 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	111/238 (47%)
		pp-GalNAc-T	153..457	CDD:133004	138/309 (45%)
		Ricin_B_lectin	516..658	CDD:279046
		RICIN	524..660	CDD:238092
GALNTL5	XP_016867282.1	GT2	187..437	CDD:224137	116/258 (45%)
GALNTL5	XP_016867282.1	pp-GalNAc-T	190..486	CDD:133004	138/309 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820