DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant3 and Galnt4

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_056552.1	Gene:	Galnt4 / 14426	MGIID:	894692	Length:	578	Species:	Mus musculus

Alignment Length:	693	Identity:	249/693 - (35%)
Similarity:	327/693 - (47%)	Gaps:	150/693 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGLRFQQLKKLWLLYLFLLFFAFFMFAISINLYVASIQGGDAEMRHPKPPPKRRSLWPHKNIVAH 65
            |.:|:....|..|| |.||..|:.:...|::...||...|.|....|:..|
Mouse     1 MAVRWTWAGKSCLL-LALLTLAYILVEFSVSTLYASPGAGGARELGPRRLP-------------- 50

  Fly    66 YIGKGDIFGNMTADDYNINLFQPINGEGADGRPVVVPPRDRFRMQRFFR-----LN--------- 116
                 |:      |....:|.||:         .:.||.|...:..:.|     ||
Mouse    51 -----DL------DTREEDLSQPL---------YIKPPADSHALGEWGRASKLQLNEGELKQQEE 95

  Fly   117 -----SFNLLASDRIPLNRTLKDYRTPECRDKKY-ASGLPSTSVIIVFHNEAWSVLLRTITSVIN 175
                 :.|:..||||.|:|.::|.|..||:.||: ...||:|||||.|:|||||.|||||.||:.
Mouse    96 LIERYAINIYLSDRISLHRHIEDKRMYECKAKKFHYRSLPTTSVIIAFYNEAWSTLLRTIHSVLE 160

  Fly   176 RSPRHLLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLT 240
            .||..||||||||||.|||.|||.|||:|:..|. ..|:.|..||.|||.|||:||..|.|||||
Mouse   161 TSPAVLLKEIILVDDLSDRIYLKAQLETYISNLE-RVRLIRTNKREGLVRARLIGATFATGDVLT 224

  Fly   241 FLDAHCECSRGWLEPLLSRIKESRKVVICPVIDIISDDNFS-YTKTFENHWGAFNWQLSFRWFS- 303
            |||.||||:.|||||||.||......::|||||.|..:.|. |.:|.|...|.|:|:|:|:|.|
Mouse   225 FLDCHCECNTGWLEPLLERISRDETAIVCPVIDTIDWNTFEFYMQTGEPMIGGFDWRLTFQWHSV 289

  Fly   304 --SDRKRQTAGNSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQC 366
              .:|.|:|:      ..|||.:|.|||||||:.:|||..:|:||:.|.||||||:|:|||:|||
Mouse   290 PKHERDRRTS------RIDPIRSPTMAGGLFAVSKKYFQYLGTYDTGMEVWGGENLELSFRVWQC 348

  Fly   367 GGRVEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNLARAATVWMDDW-QYFIMLYTSGLTLGAKD 430
            ||::||.|||||||||....||..|.     ...|.||||.||||:: ::|   |........:.
Mouse   349 GGKLEIHPCSHVGHVFPKRAPYARPN-----FLQNTARAAEVWMDEYKEHF---YNRNPPARKEA 405

  Fly   431 KVNVTERVALRERLQCKPFSWYLENIWPEHFFPAPDRFFGKIIWLDGETECAQAYSKHMKNLPGR 495
            ..:::||..|||||:||.|.|||:|::.....| .||                         ||
Mouse   406 YGDLSERKLLRERLKCKSFDWYLKNVFSNLHVP-EDR-------------------------PG- 443

  Fly   496 ALSREWKRAFEEIDSKAEELMALIDLERDKCLRPLKEDVPRSSLSAVTVGDCTSHAQSMDMFV-I 559
                 |..|...:...:|            |   |..:.|.::.:...:.....|.|..:.|. .
Mouse   444 -----WHGAIRSMGISSE------------C---LDYNAPDNNPTGANLSLFGCHGQGGNQFFEY 488

  Fly   560 TPKGQIMTND--NVCLTYRQQKLGVIKMLKNRNATTSNVMLAQCASDS-----SQLWTYDMDTQQ 617
            |...:|..|.  .:|....|||              ..|.:..|..|.     :.:|.:..| ..
Mouse   489 TSNKEIRFNSVTELCAEVPQQK--------------DYVGMQNCPKDGLPVPVNIIWHFKED-GT 538

  Fly   618 ISHRDTKLCLTLKAATNSRLQKVEKVVLSMECDFKDITQKWGF 660
            |.|..|:|||:.......|     ..|....||..|..|.|.|
Mouse   539 IFHPHTRLCLSAYRTAEGR-----PSVHMKTCDALDKNQLWRF 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	140/239 (59%)
		pp-GalNAc-T	153..457	CDD:133004	166/308 (54%)
		Ricin_B_lectin	516..658	CDD:279046	30/149 (20%)
		RICIN	524..660	CDD:238092	31/143 (22%)
Galnt4	NP_056552.1	WcaA	133..430	CDD:223539	168/311 (54%)
		Catalytic subdomain A	134..243		75/109 (69%)
		pp-GalNAc-T	138..432	CDD:133004	166/308 (54%)
		Catalytic subdomain B	303..365		42/61 (69%)
		RICIN	446..576	CDD:238092	33/164 (20%)
		Ricin_B_lectin	446..574	CDD:279046	32/162 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820