DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant3 and GALNT13

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001363332.1	Gene:	GALNT13 / 114805	HGNCID:	23242	Length:	571	Species:	Homo sapiens

Alignment Length:	657	Identity:	271/657 - (41%)
Similarity:	362/657 - (55%)	Gaps:	133/657 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LWLLY-LFLLFFAFFMFAISINLYVASIQGGDAEMRHPKPPPKRRSLWPHKNIVAHYIGKGDIFG 74
            :|:|. :|||            ||.:.....|.:        |.|||.|....|        |..
Human    16 MWVLVDVFLL------------LYFSECNKCDDK--------KERSLLPALRAV--------ISR 52

  Fly    75 NMTADDYNINLFQPINGEGADGRPVVVPPRDRFRMQRFFRLNSFNLLASDRIPLNRTLKDYRTPE 139
            |.             .|.|..|:.|::|..|:.:|:..|::|.|||:|||.|.|||:|.|.|...
Human    53 NQ-------------EGPGEMGKAVLIPKDDQEKMKELFKINQFNLMASDLIALNRSLPDVRLEG 104

  Fly   140 CRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLESY 204
            |:.|.|...||:|||:|||||||||.||||:.|||||||.:||.|:|||||||:|.:||..||:|
Human   105 CKTKVYPDELPNTSVVIVFHNEAWSTLLRTVYSVINRSPHYLLSEVILVDDASERDFLKLTLENY 169

  Fly   205 VKVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVIC 269
            ||.|.||.:|.||::||||:.|||.||..::|.|:|||||||||:.|||||||:||||.||.|:|
Human   170 VKNLEVPVKIIRMEERSGLIRARLRGAAASKGQVITFLDAHCECTLGWLEPLLARIKEDRKTVVC 234

  Fly   270 PVIDIISDDNFSYTKTFENHWGAFNWQLSFRWF-----SSDRKRQTAGNSSKDSTDPIATPGMAG 329
            |:||:||||.|.|....:..:|.|||:|:|||:     ..||::       .|.|.|:.||.|||
Human   235 PIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRK-------GDRTLPVRTPTMAG 292

  Fly   330 GLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGM 394
            |||:|||.||.|:|:||:.|.:|||||:|||||||||||.:||..|||||||||.:||||||||.
Human   293 GLFSIDRNYFEEIGTYDAGMDIWGGENLEMSFRIWQCGGSLEIVTCSHVGHVFRKATPYTFPGGT 357

  Fly   395 SEVLTDNLARAATVWMDDWQYFIMLYTSGLTLGAKDKVNVTERVALRERLQCKPFSWYLENIWPE 459
            ..|:..|..|.|.||||:::.|..:.:.|:.  ..|..:|:.|..|||.|:|||||||||||:|:
Human   358 GHVINKNNRRLAEVWMDEFKDFFYIISPGVV--KVDYGDVSVRKTLRENLKCKPFSWYLENIYPD 420

  Fly   460 HFFPAPDRFFGKIIWLDGETECAQAYSKHMKNLPGRALSREWKRAFEEIDSKAEELMALIDLERD 524
            .  ..|.|::                                            .|..:.::|.:
Human   421 S--QIPRRYY--------------------------------------------SLGEIRNVETN 439

  Fly   525 KCLRPLKEDVPRSSLSAVTVGDCTSHAQ-SMDMFVITPKGQIMTNDNVCLTYRQQKLGVIKMLKN 588
            :||    :::.|.....|.:.:|  |.. ...:|..|...:|.| |::||...:.. |.:.|||.
Human   440 QCL----DNMGRKENEKVGIFNC--HGMGGNQVFSYTADKEIRT-DDLCLDVSRLN-GPVIMLKC 496

  Fly   589 RNATTSNVMLAQCASDSSQLWTYDMDTQQISHRDTKLCLTL-KAATNSRLQKVEKVVLSMECDFK 652
            .:..            .:|||.||.:|..:.|..|:.||:: |.|..|:...||      .|:
Human   497 HHMR------------GNQLWEYDAETHTLLHIITQSCLSVNKVADGSQHPTVE------TCN-- 541

  Fly   653 DIT-QKW 658
            |.| |||
Human   542 DSTLQKW 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	150/240 (63%)
		pp-GalNAc-T	153..457	CDD:133004	183/308 (59%)
		Ricin_B_lectin	516..658	CDD:279046	37/144 (26%)
		RICIN	524..660	CDD:238092	38/138 (28%)
GALNT13	NP_001363332.1	pp-GalNAc-T	118..418	CDD:133004	183/308 (59%)
GALNT13	NP_001363332.1	Ricin_B_lectin	431..548	CDD:395527	37/144 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194016at33208
OrthoFinder	1	1.000	-	-		FOG0002015
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11675
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920