Protein Alignment Pgant3 and GALNT5

DIOPT Version :10

• Sequence 1: NP_610256.1
• Gene: Pgant3 / 35627
• FlyBaseID: FBgn0027558
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: XP_016858726.1
• Gene: GALNT5 / 11227
• HGNCID: 4127
• Length: 956
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 218/601 - (36%)
• Similarity: 306/601 - (50%)
• Gaps: 122/601 - (20%)

  Fly    93 GADGRPVVVPPRDRFRMQRFFRLNSFNLLASDRIPLNRTLKDYRTPECRDKKYASGLPSTSVIIV 157
            |..|||||||.......:|.::..:||:..||.||::|.::|.|...|.::...:.||:||||:.
Human   439 GQFGRPVVVPHGKEKEAERRWKEGNFNVYLSDLIPVDRAIEDTRPAGCAEQLVHNNLPTTSVIMC 503

  Fly   158 FHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRSG 222
            |.:|.||.|||::.|||||||.||:|||:||||.|.:.|||..|:.|:.... ..||.|:|:|.|
Human   504 FVDEVWSTLLRSVHSVINRSPPHLIKEILLVDDFSTKDYLKDNLDKYMSQFP-KVRILRLKERHG 567

  Fly   223 LVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVICPVIDIISDDNFSYTKTFE 287
            |:.|||.||:||.||||||||:|.||:.|||||||.|:..|||.|.||||::|:|.:.||.....
Human   568 LIRARLAGAQNATGDVLTFLDSHVECNVGWLEPLLERVYLSRKKVACPVIEVINDKDMSYMTVDN 632

  Fly   288 NHWGAFNWQLSFRWFSSDRKRQT------AGNSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYD 346
            ...|.|.|.::|.|       :|      |.|..|: ||.|..|.||||||:||:.||:|:|:||
Human   633 FQRGIFVWPMNFGW-------RTIPPDVIAKNRIKE-TDTIRCPVMAGGLFSIDKSYFFELGTYD 689

  Fly   347 SNMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNLARAATVWMD 411
            ..:.||||||:|:||::|.|||.:||.|||.|||:||:..||:||....:.:..||.|.|.||:|
Human   690 PGLDVWGGENMELSFKVWMCGGEIEIIPCSRVGHIFRNDNPYSFPKDRMKTVERNLVRVAEVWLD 754

  Fly   412 DWQYFIM-----LYTSGLTLGAKDKVNVTERVALRERLQCKPFSWYLENIWPEHFFPAP------ 465
            :::....     |...||.:|     |:|::..||::|:||.|.|||||::|:  ..||
Human   755 EYKELFYGHGDHLIDQGLDVG-----NLTQQRELRKKLKCKSFKWYLENVFPD--LRAPIVRASG 812

  Fly   466 ---DRFFGKIIWLDGET----ECAQAYSKHMKNLPGRALSR--EWKRAFEEIDSKAEELMALIDL 521
               :...||.|.::..|    :|..:......|.....|.:  ||
Human   813 VLINVALGKCISIENTTVILEDCDGSKELQQFNYTWLRLIKCGEW-------------------- 857

  Fly   522 ERDKCLRPLKEDVPRSSLSAVTVGDCTSHAQSMDMFVITPKGQIMTNDNVCLTYRQQKLGVI--K 584
                |:.|:.:.      .||.:..|                   .|.|..|.:..:...|.  :
Human   858 ----CIAPIPDK------GAVRLHPC-------------------DNRNKGLKWLHKSTSVFHPE 893

  Fly   585 MLKNRNATTSNVMLAQCASDSSQLWTYDMDTQQISH-----RDTKLCLTLKAATNSRLQKVEKVV 644
            :|.|          :.|.|..:.|      :.|::|     ....|||     ..:..||:.||.
Human   894 LLSN----------SACGSFPALL------SLQVNHIVFENNQQLLCL-----EGNFSQKILKVA 937

  Fly   645 LSMECDFKDITQKWGF 660
               .||.....|||.|
Human   938 ---ACDPVKPYQKWKF 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	pp-GalNAc-T	153..457	CDD:133004	155/314 (49%)
		beta-trefoil_Ricin_Pgant3-like	515..661	CDD:467338	29/153 (19%)
GALNT5	XP_016858726.1	pp-GalNAc-T	499..800	CDD:133004	155/314 (49%)
		beta-trefoil_Ricin_GALNT5	806..954	CDD:467314	39/218 (18%)