DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant3 and Galnt2

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_644678.2	Gene:	Galnt2 / 108148	MGIID:	894694	Length:	570	Species:	Mus musculus

Alignment Length:	643	Identity:	228/643 - (35%)
Similarity:	314/643 - (48%)	Gaps:	127/643 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LFLLFFAFFMFAISINLYVASIQGGDA---------------EMRHPK-----------PPPKRR 54
            |::|..|::|::...:...|.  ||.|               ::.|.:           ||.|.|
Mouse    14 LWVLGIAYYMYSGGGSALAAG--GGGAGRKGDWNDIDSIKKKDLHHSRGDEKAQGVETLPPGKVR 76

  Fly    55 SLWPHKNIVAHYIGKGDIFGNMTADDYNINLFQPINGEGADGRPVVVPPRDRFRMQRFFRLNSFN 119
              ||..|..| |:|     |.|..             .|.|       |..|         |.||
Mouse    77 --WPDFNQEA-YVG-----GTMVR-------------SGQD-------PYAR---------NKFN 104

  Fly   120 LLASDRIPLNRTLKDYRTPECRDKKYASGLPSTSVIIVFHNEAWSVLLRTITSVINRSPRHLLKE 184
            .:.||::.::|.:.|.|..:|:.|::...||:|||:|.|||||.|.||||:.||:.|||.||:||
Mouse   105 QVESDKLHMDRGIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKRSPPHLIKE 169

  Fly   185 IILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRSGLVPARLLGAENARGDVLTFLDAHCECS 249
            ||||||.|:.......|....||     |:.|..:|.||:.:|:.||:.|:..||||||:||||:
Mouse   170 IILVDDYSNDPEDGALLGKIEKV-----RVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECN 229

  Fly   250 RGWLEPLLSRIKESRKVVICPVIDIISDDNFSYTKTFENHWGAFNWQLSFRW--FSSDRKRQTAG 312
            ..||||||.|:.|.|..|:.|:||:|:.|||.|.....:..|.|:|.|.|:|  .:.:::|...|
Mouse   230 ERWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQG 294

  Fly   313 NSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDSNMRVWGGENVEMSFRIWQCGGRVEISPCSH 377
            |    ...||.||.:|||||.:|:.||.|:|.||..|.||||||:|:|||:|||||.:||.|||.
Mouse   295 N----PVAPIKTPMIAGGLFVMDKLYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSR 355

  Fly   378 VGHVFRSSTPYTFPGGMSEVLTDNLARAATVWMDDWQYFIMLYTSGLTLGAKDKVNVTERVALRE 442
            ||||||...|||||||...|...|..|||.||||::::|  .|.:..:.......|:..|:.||:
Mouse   356 VGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKHF--YYAAVPSARNVPYGNIQSRLELRK 418

  Fly   443 RLQCKPFSWYLENIWPEHFFP-APDRFFGKIIWLDGETECAQA-----------YSKHMKNLPGR 495
            :|.||||.|||:|::||...| ..|..||.   |...|.|...           |..|  |..|
Mouse   419 KLGCKPFKWYLDNVYPELRVPDHQDIAFGA---LQQGTNCLDTLGHFADGVVGIYECH--NAGG- 477

  Fly   496 ALSREWKRAFEEIDSKAEELMALIDLERDKCLRPLKEDVPRSSLSAVTVGDCTSHAQSMDMFVIT 560
              ::||....|    |:.:.|       |.||..    |.||..|.:.:..|..:........|.
Mouse   478 --NQEWALTKE----KSVKHM-------DLCLTV----VDRSPGSLIRLQGCRENDSRQKWEQIE 525

  Fly   561 PKGQIM-TNDNVCLTYRQQKLGVIKMLKNRNATTSNVMLAQCASDSSQLWTYDMDTQQ 617
            ...::. ...|:|             |.:|.|.:..:.:..|....||.|.:.::.||
Mouse   526 GNSKLRHVGSNLC-------------LDSRTAKSGGLSVEVCGPALSQQWKFSLNLQQ 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	123/237 (52%)
		pp-GalNAc-T	153..457	CDD:133004	152/305 (50%)
		Ricin_B_lectin	516..658	CDD:279046	21/103 (20%)
		RICIN	524..660	CDD:238092	20/95 (21%)
Galnt2	NP_644678.2	Catalytic subdomain A	134..239		60/109 (55%)
		pp-GalNAc-T	138..433	CDD:133004	152/305 (50%)
		Catalytic subdomain B	299..361		41/61 (67%)
		Ricin_B_lectin	445..562	CDD:279046	31/152 (20%)
		RICIN	455..564	CDD:238092	28/141 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820