DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant3 and POC1B-GALNT4

DIOPT Version :9

Sequence 1:	NP_610256.1	Gene:	Pgant3 / 35627	FlyBaseID:	FBgn0027558	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001186710.1	Gene:	POC1B-GALNT4 / 100528030	HGNCID:	42957	Length:	575	Species:	Homo sapiens

Alignment Length:	647	Identity:	233/647 - (36%)
Similarity:	308/647 - (47%)	Gaps:	139/647 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VASIQGGDAEMRHP---KPPPKRRSL--WPHKNIVAHYIGKGDIFGNMTADDYNINLFQPINGEG 93
            ::.:|....::..|   |||...|:|  |          ||        |....:|
Human    46 LSDLQKNTEDLSRPLYKKPPADSRALGEW----------GK--------ASKLQLN--------- 83

  Fly    94 ADGRPVVVPPRDRFRMQ-RFFRLNSFNLLASDRIPLNRTLKDYRTPECRDKKY-ASGLPSTSVII 156
                      .|..:.| ......:.|:..||||.|:|.::|.|..||:.:|: ...||:|||||
Human    84 ----------EDELKQQEELIERYAINIYLSDRISLHRHIEDKRMYECKSQKFNYRTLPTTSVII 138

  Fly   157 VFHNEAWSVLLRTITSVINRSPRHLLKEIILVDDASDRSYLKRQLESYVKVLAVPTRIFRMKKRS 221
            .|:|||||.|||||.||:..||..||||||||||.|||.|||.|||:|:..|. ..|:.|..||.
Human   139 AFYNEAWSTLLRTIHSVLETSPAVLLKEIILVDDLSDRVYLKTQLETYISNLD-RVRLIRTNKRE 202

  Fly   222 GLVPARLLGAENARGDVLTFLDAHCECSRGWLEPLLSRIKESRKVVICPVIDIISDDNFS-YTKT 285
            |||.|||:||..|.||||||||.||||:.|||||||.||......|:|||||.|..:.|. |.:.
Human   203 GLVRARLIGATFATGDVLTFLDCHCECNSGWLEPLLERIGRDETAVVCPVIDTIDWNTFEFYMQI 267

  Fly   286 FENHWGAFNWQLSFRWFS---SDRKRQTAGNSSKDSTDPIATPGMAGGLFAIDRKYFYEMGSYDS 347
            .|...|.|:|:|:|:|.|   .:|.|:.:      ..|||.:|.|||||||:.:|||..:|:||:
Human   268 GEPMIGGFDWRLTFQWHSVPKQERDRRIS------RIDPIRSPTMAGGLFAVSKKYFQYLGTYDT 326

  Fly   348 NMRVWGGENVEMSFRIWQCGGRVEISPCSHVGHVFRSSTPYTFPGGMSEVLTDNLARAATVWMDD 412
            .|.||||||:|:|||:|||||::||.|||||||||....||..|.     ...|.||||.||||:
Human   327 GMEVWGGENLELSFRVWQCGGKLEIHPCSHVGHVFPKRAPYARPN-----FLQNTARAAEVWMDE 386

  Fly   413 W-QYFIMLYTSGLTLGAKDKVNVTERVALRERLQCKPFSWYLENIWPEHFFPAPDRFFGKIIWLD 476
            : ::|   |........:...:::||..|||||:||.|.|||:|::|....| .||
Human   387 YKEHF---YNRNPPARKEAYGDISERKLLRERLRCKSFDWYLKNVFPNLHVP-EDR--------- 438

  Fly   477 GETECAQAYSKHMKNLPGRALSREWKRAFEEIDSKAEELMALIDLERDKCLRPLKEDVPRSSLSA 541
                            ||      |..|.......:|            |   |..:.|.::.:.
Human   439 ----------------PG------WHGAIRSRGISSE------------C---LDYNSPDNNPTG 466

  Fly   542 VTVGDCTSHAQSMDMFV-ITPKGQIMTND--NVCLTYRQQKLGVIKMLKNRNATTSNVMLAQCAS 603
            ..:.....|.|..:.|. .|...:|..|.  .:|....:||              :.|.:..|..
Human   467 ANLSLFGCHGQGGNQFFEYTSNKEIRFNSVTELCAEVPEQK--------------NYVGMQNCPK 517

  Fly   604 D-----SSQLWTYDMDTQQISHRDTKLCLTLKAATNSRLQKVEKVVLSMECDFKDITQKWGF 660
            |     ::.:|.:..| ..|.|..:.|||:.......|..     |....||..|..|.|.|
Human   518 DGFPVPANIIWHFKED-GTIFHPHSGLCLSAYRTPEGRPD-----VQMRTCDALDKNQIWSF 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant3	NP_610256.1	Glyco_tranf_2_3	150..386	CDD:290369	139/239 (58%)
		pp-GalNAc-T	153..457	CDD:133004	165/308 (54%)
		Ricin_B_lectin	516..658	CDD:279046	28/149 (19%)
		RICIN	524..660	CDD:238092	29/143 (20%)
POC1B-GALNT4	NP_001186710.1	WcaA	131..427	CDD:223539	167/310 (54%)
		pp-GalNAc-T	135..429	CDD:133004	165/308 (54%)
		RICIN	443..573	CDD:238092	31/164 (19%)
		Ricin_B_lectin	443..571	CDD:279046	30/162 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810