Protein Alignment Tsp42Ep and Prph2

DIOPT Version :10

• Sequence 1: NP_523642.1
• Gene: Tsp42Ep / 35626
• FlyBaseID: FBgn0033137
• Length: 250
• Species: Drosophila melanogaster
• Sequence 2: NP_032964.1
• Gene: Prph2 / 19133
• MGIID: 102791
• Length: 346
• Species: Mus musculus
• Alignment Length: 280
• Identity: 55/280 - (19%)
• Similarity: 93/280 - (33%)
• Gaps: 102/280 - (36%)

  Fly    14 LSNLLYMLLGIGVMSGAGLGLQM-----AEPNTPEHTYFVKSLVLGGSICMIVMFGCYGMVA--- 70
            |.|.|.:|.|| |:...||.|::     :|......::||.:.::|..:...|.....|.:.
Mouse    22 LMNWLSVLAGI-VLFSLGLFLKIELRKRSEVMNNSESHFVPNSLIGVGVLSCVFNSLAGKICYDA 85

  Fly    71 --------------NLLCVNLIFTMFI-LIALAAEYLQ--------------LHHYHSPSLRSPG 106
                          ..|.|.:.|.:.: |:||....|:              :.:|....  :||
Mouse    86 LDPAKYAKWKPWLKPYLAVCIFFNVILFLVALCCFLLRGSLESTLAYGLKNGMKYYRDTD--TPG 148

  Fly   107 GAWQQLELAWHGLDRDPELMHQYEASQHCCGYNGADDYKRLHLL--------------------- 150
            ..:.:..:.          |.|.|..  |||.||..|:..:..:
Mouse   149 RCFMKKTID----------MLQIEFK--CCGNNGFRDWFEIQWISNRYLDFSSKEVKDRIKSNVD 201

  Fly   151 -------VPASCYQAAVNDTAQQIYPSGCL--ETLNRSQRY-IQHR-DKLYMWAIVGLEIFIL-- 202
                   ||.||    .|.::    |..|:  :..|.|..| ..|: ::|.:| :.|....:|
Mouse   202 GRYLVDGVPFSC----CNPSS----PRPCIQYQLTNNSAHYSYDHQTEELNLW-LRGCRAALLNY 257

  Fly   203 -------LQTVALSVLLFRL 215
                   :..|.|.|.||.:
Mouse   258 YSSLMNSMGVVTLLVWLFEV 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Ep	NP_523642.1	Tetraspanin	23..213	CDD:459767	49/267 (18%)
		tetraspanin_LEL	91..183	CDD:239401	23/136 (17%)
Prph2	NP_032964.1	Tetraspanin	16..181	CDD:459767	35/173 (20%)
		peripherin_like_LEL	120..262	CDD:239415	28/164 (17%)
		Interaction with MREG. /evidence=ECO:0000269|PubMed:17260955	341..346