DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp42Eo and CD63

DIOPT Version :9

Sequence 1:	NP_523641.2	Gene:	Tsp42Eo / 35625	FlyBaseID:	FBgn0033136	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_001244318.1	Gene:	CD63 / 967	HGNCID:	1692	Length:	238	Species:	Homo sapiens

Alignment Length:	196	Identity:	47/196 - (23%)
Similarity:	81/196 - (41%)	Gaps:	64/196 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LILAGLVGCLGAIFGSIKVMV-----VNLILLL---ALIASHIWK---VSHYNETKQLDATEVYV 110
            |.|...|||.||...:..:|:     ::||:|:   |.||.::::   :|.:|...:..
Human    64 LFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQ------ 122

  Fly   111 MDLWMKELVHHGA--MQDLQQEYECCGDKGFSDYTSL----NMKVPRSC-----------FHTKD 158
            |:.:.|.  :|.|  :..:|.:::|||...::|:..:    ..:||.||           |:.|
Human   123 MENYPKN--NHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEK- 184

  Fly   159 GIHALYPYGEGCMAAVKRAYLQIYRYEK---WVHCG--LIGYEVVGI----ILGITLCCQLTNKT 214
            .||.     |||:             ||   |:...  ::....:||    :|||...|.|....
Human   185 AIHK-----EGCV-------------EKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSI 231

  Fly   215 R 215
            |
Human   232 R 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Eo	NP_523641.2	Tetraspannin	7..210	CDD:278750	45/189 (24%)
Tsp42Eo	NP_523641.2	tetraspanin_LEL	110..178	CDD:239401	20/84 (24%)
CD63	NP_001244318.1	Tetraspannin	10..227	CDD:395265	45/189 (24%)
		CD63_LEL	105..203	CDD:239419	25/124 (20%)
		Lysosomal targeting motif. /evidence=ECO:0000250\|UniProtKB:P41731	234..238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810