Protein Alignment Tsp42Eo and TSPAN8

DIOPT Version :10

• Sequence 1: NP_523641.2
• Gene: Tsp42Eo / 35625
• FlyBaseID: FBgn0033136
• Length: 219
• Species: Drosophila melanogaster
• Sequence 2: NP_004607.1
• Gene: TSPAN8 / 7103
• HGNCID: 11855
• Length: 237
• Species: Homo sapiens
• Alignment Length: 250
• Identity: 58/250 - (23%)
• Similarity: 103/250 - (41%)
• Gaps: 50/250 - (20%)

  Fly     1 MPTVRVCLQWTSVVFSTLTLIVGVL-AALAGVYELDKFNE--------GSAEHTEKFVQLGMAGA 56
            |..|..|::::...|:.|..:.|:| .|||....:...::        ||:.:....:.:.:...
Human     1 MAGVSACIKYSMFTFNFLFWLCGILILALAIWVRVSNDSQAIFGSEDVGSSSYVAVDILIAVGAI 65

  Fly    57 LILAGLVGCLGAIFGS---IKVMVVNLILLLAL-----IASHIWKVSH--------YNETKQLDA 105
            :::.|.:||.|||..|   :.:..:.|:|:|.|     |...::|...        |..||.|.|
Human    66 IMILGFLGCCGAIKESRCMLLLFFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYENTKLLSA 130

  Fly   106 TEVYVMDLWMKELVHHGAMQDLQQEYECCG------DKG--FSDY----TSLNMKVPRSCFHTKD 158
            |       ...|.....|:...|:|::|||      |.|  |..|    ..|:.:.|...::.|.
Human   131 T-------GESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNFQHYPELCACLDKQRPCQSYNGKQ 188

  Fly   159 GIHALYPYGEGCMAAVKRAYLQIYRYEKWVHCGLIGYEVVGIILGITLCCQLTNK 213
                  .|.|.|::.:|....:.......:..||...|::|::..:.|.||:.||
Human   189 ------VYKETCISFIKDFLAKNLIIVIGISFGLAVIEILGLVFSMVLYCQIGNK 237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Eo	NP_523641.2	Tetraspanin	8..208	CDD:459767	51/236 (22%)
		tetraspanin_LEL	110..178	CDD:239401	18/79 (23%)
TSPAN8	NP_004607.1	Tetraspanin	8..232	CDD:459767	51/236 (22%)
		hydrophobic region	10..33		7/22 (32%)
		hydrophobic region	58..78		4/19 (21%)
		hydrophobic region	83..109		5/25 (20%)
		TM4SF3_like_LEL	106..206	CDD:239407	25/112 (22%)
		hydrophobic region	206..232		5/25 (20%)