DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp42Eo and Cd63

DIOPT Version :9

Sequence 1:	NP_523641.2	Gene:	Tsp42Eo / 35625	FlyBaseID:	FBgn0033136	Length:	219	Species:	Drosophila melanogaster
Sequence 2:	NP_001036045.1	Gene:	Cd63 / 12512	MGIID:	99529	Length:	238	Species:	Mus musculus

Alignment Length:	228	Identity:	51/228 - (22%)
Similarity:	93/228 - (40%)	Gaps:	55/228 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VGVLA---ALAGVYELDKFNEGSAEHTEKFVQLGMAGALILAGLVGCLGAIFGSIKVMV-----V 78
            ||::|   |:..|.:....:|.:|......|.:.:...|.|...|||.||...:..:|:     :
Mouse    26 VGLIAIGVAVQVVLKQAITHETTAGSLLPVVIIAVGAFLFLVAFVGCCGACKENYCLMITFAIFL 90

  Fly    79 NLILLLAL---IASHIWK---VSHYNETKQLDATEVYVMDLWMKELVHHGAMQDLQQEYECCGDK 137
            :||:|:.:   ||.::::   .|.:|::.|..      |..::|:......:..||:|..|||..
Mouse    91 SLIMLVEVAVAIAGYVFRDQVKSEFNKSFQQQ------MQNYLKDNKTATILDKLQKENNCCGAS 149

  Fly   138 GFSDYTSL----NMKVPRSCF----------HTKDGIHALYPYGEGCMAAVKRAYLQIYRYEKWV 188
            .::|:.::    ..:||.||.          ..:..||.     :||:..:          ..|:
Mouse   150 NYTDWENIPGMAKDRVPDSCCINITVGCGNDFKESTIHT-----QGCVETI----------AIWL 199

  Fly   189 HCG--LIGYEVVGI----ILGITLCCQLTNKTR 215
            ...  |:....:||    :|||...|.|....|
Mouse   200 RKNILLVAAAALGIAFVEVLGIIFSCCLVKSIR 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Eo	NP_523641.2	Tetraspannin	7..210	CDD:278750	49/221 (22%)
Tsp42Eo	NP_523641.2	tetraspanin_LEL	110..178	CDD:239401	17/81 (21%)
Cd63	NP_001036045.1	Tetraspannin	10..227	CDD:395265	49/221 (22%)
		CD63_LEL	105..203	CDD:239419	21/118 (18%)
		Lysosomal targeting motif. /evidence=ECO:0000269\|PubMed:21041449	234..238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810