DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp42En and CD63

DIOPT Version :9

Sequence 1:	NP_001260758.1	Gene:	Tsp42En / 35624	FlyBaseID:	FBgn0033135	Length:	218	Species:	Drosophila melanogaster
Sequence 2:	NP_001244318.1	Gene:	CD63 / 967	HGNCID:	1692	Length:	238	Species:	Homo sapiens

Alignment Length:	233	Identity:	55/233 - (23%)
Similarity:	94/233 - (40%)	Gaps:	63/233 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LKAVLIVLNVLL--------SLIGVTL---IALSVYELNSSTPGTFEHIAIVVQIFVGTFVVLTS 61
            :|.|..:|.|||        .||.|.:   :.||...:..:|||:   :..||.|.||.|:.|.:
Human     7 MKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGS---LLPVVIIAVGVFLFLVA 68

  Fly    62 FLGCFATARVSLGLVWSYVICLLILLCLQIYIIAAAHSTDYVERSK--KDFLATWADQRTNVER- 123
            |:||....:.:..|:.::.|.|.:::.:::    ||....||.|.|  .:|...:..|..|..:
Human    69 FVGCCGACKENYCLMITFAIFLSLIMLVEV----AAAIAGYVFRDKVMSEFNNNFRQQMENYPKN 129

  Fly   124 ------ISLLEQKYSCCGQLGAHDY------------------ILMGRGIPLSCYKDQERREYSL 164
                  :..::..:.|||.....|:                  :.:|.||..:        |.::
Human   130 NHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFN--------EKAI 186

  Fly   165 FSGGCLQAVQAHATDNVAIGLIIKWLLLLVEFAALGAA 202
            ...||::.:......||          |:|..||||.|
Human   187 HKEGCVEKIGGWLRKNV----------LVVAAAALGIA 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42En	NP_001260758.1	Tetraspannin	8..199	CDD:278750	51/228 (22%)
Tsp42En	NP_001260758.1	tetraspanin_LEL	96..180	CDD:239401	19/110 (17%)
CD63	NP_001244318.1	Tetraspannin	10..227	CDD:395265	54/230 (23%)
		CD63_LEL	105..203	CDD:239419	17/105 (16%)
		Lysosomal targeting motif. /evidence=ECO:0000250\|UniProtKB:P41731	234..238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810