Protein Alignment Tsp42En and TSPAN7

DIOPT Version :10

• Sequence 1: NP_523640.1
• Gene: Tsp42En / 35624
• FlyBaseID: FBgn0033135
• Length: 218
• Species: Drosophila melanogaster
• Sequence 2: NP_004606.2
• Gene: TSPAN7 / 7102
• HGNCID: 11854
• Length: 249
• Species: Homo sapiens
• Alignment Length: 224
• Identity: 55/224 - (24%)
• Similarity: 93/224 - (41%)
• Gaps: 49/224 - (21%)

  Fly     8 LKAVLIVLNVLLSLIGVTLIALSVYELNSSTPGTFEHIAIV---------VQIFVGTFVVLTSFL 63
            ||.:||:.:.:..:.||.|:|:.|:  ...|.||:  |:::         |.|..||.:|:....
Human    15 LKTLLIIYSFVFWITGVILLAVGVW--GKLTLGTY--ISLIAENSTNAPYVLIGTGTTIVVFGLF 75

  Fly    64 GCFATARVSLGLVWSYVICLLILLCLQIYIIAAAHSTDYVERSKKDFLATWAD----QRTNVER- 123
            |||||.|.|..::..|.:.|.::...:  ::|......:....|..||.|:.|    ...|.||
Human    76 GCFATCRGSPWMLKLYAMFLSLVFLAE--LVAGISGFVFRHEIKDTFLRTYTDAMQTYNGNDERS 138

  Fly   124 --ISLLEQKYSCCGQLGAHDY-------ILMGRGIPLSCYKD------QERREYSLFS-----GG 168
              :..:::..|||   |..:|       ..:..|||.||..:      |:....::.:     .|
Human   139 RAVDHVQRSLSCC---GVQNYTNWSTSPYFLEHGIPPSCCMNETDCNPQDLHNLTVAATKVNQKG 200

  Fly   169 CLQAVQAHATDN------VAIGLIIKWLL 191
            |...|.:....|      ||.|:....|:
Human   201 CYDLVTSFMETNMGIIAGVAFGIAFSQLI 229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42En	NP_523640.1	Tetraspanin	8..>135	CDD:459767	38/142 (27%)
		tetraspanin_LEL	96..180	CDD:239401	22/108 (20%)
TSPAN7	NP_004606.2	Tetraspanin	15..239	CDD:459767	55/224 (25%)
		TM4SF2_6_like_LEL	110..213	CDD:239414	22/105 (21%)