DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment lbm and CD63

DIOPT Version :9

Sequence 1:NP_001260757.1 Gene:lbm / 35623 FlyBaseID:FBgn0016032 Length:208 Species:Drosophila melanogaster
Sequence 2:NP_001244318.1 Gene:CD63 / 967 HGNCID:1692 Length:238 Species:Homo sapiens


Alignment Length:231 Identity:47/231 - (20%)
Similarity:99/231 - (42%) Gaps:41/231 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 VKIASIVLNAVLGFLAAGAIGWIAYNADTE---TEEFVIAAYIACSLILVFALLGIF-------- 61
            :|....:|..:|....|.|:|.||.....:   ::..:..|.....|.:|...:|:|        
Human     7 MKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVG 71

  Fly    62 --AAIRESVVLTATSAVFLLILAILQIVSTCL-------FLHEFDVKSGRDMVEVAWQANN---- 113
              .|.:|:..|..|.|:||.::.::::.:...       .:.||: .:.|..:| .:..||    
Human    72 CCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFN-NNFRQQME-NYPKNNHTAS 134

  Fly   114 -MDSLQQKHECCGQSSAQDYIHLSLL----IPPSCYAD------LQQTPDHLYLDGCIEKVQSFY 167
             :|.:|...:|||.::..|:..:..:    :|.||..:      :......::.:||:||:..:.
Human   135 ILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKEGCVEKIGGWL 199

  Fly   168 ESDKLRFIIVSWVL-VAF-ELICFALAVFLAISFKN 201
            ..:.|  ::.:..| :|| |::....|..|..|.::
Human   200 RKNVL--VVAAAALGIAFVEVLGIVFACCLVKSIRS 233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lbmNP_001260757.1 Tetraspannin 8..198 CDD:278750 46/226 (20%)
tetraspanin_LEL <109..169 CDD:239401 15/74 (20%)
CD63NP_001244318.1 Tetraspannin 10..227 CDD:395265 44/220 (20%)
CD63_LEL 105..203 CDD:239419 19/99 (19%)
Lysosomal targeting motif. /evidence=ECO:0000250|UniProtKB:P41731 234..238 47/231 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3882
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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