DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp42El and CD63

DIOPT Version :9

Sequence 1:	NP_523638.1	Gene:	Tsp42El / 35622	FlyBaseID:	FBgn0033134	Length:	217	Species:	Drosophila melanogaster
Sequence 2:	NP_001244318.1	Gene:	CD63 / 967	HGNCID:	1692	Length:	238	Species:	Homo sapiens

Alignment Length:	221	Identity:	53/221 - (23%)
Similarity:	95/221 - (42%)	Gaps:	48/221 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CATGTIKYSLFLFNALWAILGILVLIFGGLGWGAMPDA-YAIGILILGGTILVISLFGCCGAVRE 66
            ||.|.|...          :|..:::...:..||.|.: ..:.|:.:|..:.:::..|||||.:|
Human    24 CAVGLIAVG----------VGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKE 78

  Fly    67 SPRMLWTYASLLLILLLLIVAFIILNPKDVFKKYALQTVENQW--ELEQTKPGS-----MDIIQK 124
            :..::.|:|..|.:::|:.||..|..  .||:...:....|.:  ::|.....:     :|.:|.
Human    79 NYCLMITFAIFLSLIMLVEVAAAIAG--YVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQA 141

  Fly   125 TYYCCGRDSAQDYLDIKFW-------NNTVPSSCCKDDS--C---VNPLNLYVRGCLIKVEEAFA 177
            .:.|||   |.:|.|   |       .|.||.|||.:.:  |   .|...::..||:.|:.
Human   142 DFKCCG---AANYTD---WEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKEGCVEKIG---- 196

  Fly   178 DEATTLGYLEWGLLGFNAVILLLAII 203
                  |:|...:|...|..|.:|.:
Human   197 ------GWLRKNVLVVAAAALGIAFV 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42El	NP_523638.1	Tetraspannin	7..196	CDD:278750	47/208 (23%)
Tsp42El	NP_523638.1	tetraspanin_LEL	94..178	CDD:239401	24/102 (24%)
CD63	NP_001244318.1	Tetraspannin	10..227	CDD:395265	53/221 (24%)
		CD63_LEL	105..203	CDD:239419	26/113 (23%)
		Lysosomal targeting motif. /evidence=ECO:0000250\|UniProtKB:P41731	234..238
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3882
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810