Protein Alignment Tsp42El and TSPAN14

DIOPT Version :10

• Sequence 1: NP_523638.1
• Gene: Tsp42El / 35622
• FlyBaseID: FBgn0033134
• Length: 217
• Species: Drosophila melanogaster
• Sequence 2: NP_112189.2
• Gene: TSPAN14 / 81619
• HGNCID: 23303
• Length: 270
• Species: Homo sapiens
• Alignment Length: 216
• Identity: 45/216 - (20%)
• Similarity: 92/216 - (42%)
• Gaps: 56/216 - (25%)

  Fly     9 KYSLFLFNALWAILGILVLIFGGLGW---GAMPDAYAIG----------ILILGGTILVISLFGC 60
            ||.||.:|.::.:.|::.|..|...|   |.:.|...:.          :|::|..:..:...||
Human    16 KYLLFSYNIIFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMVGVVMFTLGFAGC 80

  Fly    61 CGAVRESPRMLWTYASLLLILLLL-----IVAFIILN-PKDVFKKY---ALQTVENQWELEQTKP 116
            .||:||:..:|..:...::::..|     ::||:..: .:|.|:::   .:::..:..:|:..
Human    81 VGALRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNL-- 143

  Fly   117 GSMDIIQKTYYCCGRDSAQDYLDIKFWNNT-----------VPSSCCKDDSCVNPLN-------- 162
              :|.:||...|||....:|: |:..:.|.           ||.|||..|.....:|
Human   144 --IDSLQKANQCCGAYGPEDW-DLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVR 205

  Fly   163 ----------LYVRGCLIKVE 173
                      ::.:||:..:|
Human   206 IQLKSKWDESIFTKGCIQALE 226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42El	NP_523638.1	Tetraspanin	8..>130	CDD:459767	30/142 (21%)
		tetraspanin_LEL	94..178	CDD:239401	22/112 (20%)
TSPAN14	NP_112189.2	Tetraspanin	16..258	CDD:459767	45/216 (21%)
		TM4SF9_like_LEL	113..233	CDD:239412	23/119 (19%)
		Necessary and sufficient for interaction with ADAM10. /evidence=ECO:0000269|PubMed:26668317	114..232		22/118 (19%)