Protein Alignment Tsp42El and ROM1

DIOPT Version :10

• Sequence 1: NP_523638.1
• Gene: Tsp42El / 35622
• FlyBaseID: FBgn0033134
• Length: 217
• Species: Drosophila melanogaster
• Sequence 2: NP_000318.2
• Gene: ROM1 / 6094
• HGNCID: 10254
• Length: 351
• Species: Homo sapiens
• Alignment Length: 287
• Identity: 63/287 - (21%)
• Similarity: 96/287 - (33%)
• Gaps: 108/287 - (37%)

  Fly    12 LFLFNALWAILGILVLIFGG--------LGWGAMPD---------AYAIGILILGGTILVISLFG 59
            |:|.:.|.|:.|.::|:..|        ||....|.         |.|.|.:.||..::.:
Human    21 LWLLSWLLALAGGVILLCSGHLLVQLRHLGTFLAPSCQFPVLPQAALAAGAVALGTGLVGV---- 81

  Fly    60 CCGAVRES------PRMLWTYASLL---------LILLLLIVAFIILNPKDVFKKYALQTVENQW 109
              ||.|.|      |........||         |:::.|.:|..:....|...:..|.|....:
Human    82 --GASRASLNAALYPPWRGVLGPLLVAGTAGGGGLLVVGLGLALALPGSLDEALEEGLVTALAHY 144

  Fly   110 ELEQTKPGS------MDIIQKTYYCCGRDSAQDYLDIK-------------------------FW 143
            : :...||.      :|.:|..|:||||...:|:..::                         :.
Human   145 K-DTEVPGHCQAKRLVDELQLRYHCCGRHGYKDWFGVQWVSSRYLDPGDRDVADRIQSNVEGLYL 208

  Fly   144 NNTVPSSCCK------------DDSCVNPL--------NLYVRGCLIKVEEAFADEATTLG---- 184
            .:.||.|||.            .||..:||        ||:.:||...:.|...|.|.|||
Human   209 TDGVPFSCCNPHSPRPCLQNRLSDSYAHPLFDPRQPNQNLWAQGCHEVLLEHLQDLAGTLGSMLA 273

  Fly   185 --------------YLEWGLLGFNAVI 197
                          ||:..|.|...||
Human   274 VTFLLQALVLLGLRYLQTALEGLGGVI 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42El	NP_523638.1	Tetraspanin	8..>130	CDD:459767	34/155 (22%)
		tetraspanin_LEL	94..178	CDD:239401	27/134 (20%)
ROM1	NP_000318.2	peripherin_like_LEL	126..265	CDD:239415	28/139 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..351