Protein Alignment Tsp42El and UPK1A

DIOPT Version :10

• Sequence 1: NP_523638.1
• Gene: Tsp42El / 35622
• FlyBaseID: FBgn0033134
• Length: 217
• Species: Drosophila melanogaster
• Sequence 2: XP_054175633.1
• Gene: UPK1A / 11045
• HGNCID: 12577
• Length: 313
• Species: Homo sapiens
• Alignment Length: 239
• Identity: 50/239 - (20%)
• Similarity: 89/239 - (37%)
• Gaps: 77/239 - (32%)

  Fly    21 ILGILVLIFGGLG------WGAMPDAYAI----GI-------------LILGGTILVISLFGCCG 62
            ::|.::::..||.      | ...|.|.:    |:             :..|.:..:::.||...
Human    22 VVGNIIILLSGLSLFAETIW-VTADQYRVYPLMGVSGKDDVFAGAWIAIFCGFSFFMVASFGVGA 85

  Fly    63 AVRESPRMLWTYASLLLILLLLIVA----------FIILNPKDVFKK----YALQTVENQWELEQ 113
            |:.....|:.||..|:||:.:...|          :::.||..:.|:    |:..|.:.|   |.
Human    86 ALCRRRSMVLTYLVLMLIVYIFECASCITSYTHRDYMVSNPSLITKQMLTFYSADTDQGQ---EL 147

  Fly   114 TKPGSMDIIQKTYYCCGRDSAQDYL-----------DIKF-WNNTVPSSCCKDDSCVNPLN---- 162
            |:.....:|::.  |||.....|::           ::.| |    |..||:......|||
Human   148 TRLWDRVMIEQE--CCGTSGPMDWVNFTSAFRAATPEVVFPW----PPLCCRRTGNFIPLNEEGC 206

  Fly   163 -------LYVRGCLIKVEEAFADEATTLGYLEWGLLGFNAVILL 199
                   |:.:||...:..|. |..|      ||:..|...||:
Human   207 RLGHMDYLFTKGCFEHIGHAI-DSYT------WGISWFGFAILM 243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42El	NP_523638.1	Tetraspanin	8..>130	CDD:459767	28/145 (19%)
		tetraspanin_LEL	94..178	CDD:239401	23/110 (21%)
UPK1A	XP_054175633.1	Tetraspanin	25..>163	CDD:459767	28/143 (20%)
		uroplakin_I_like_LEL	113..231	CDD:239409	26/127 (20%)