Protein Alignment Tsp42El and TSPAN2

DIOPT Version :10

• Sequence 1: NP_523638.1
• Gene: Tsp42El / 35622
• FlyBaseID: FBgn0033134
• Length: 217
• Species: Drosophila melanogaster
• Sequence 2: NP_005716.2
• Gene: TSPAN2 / 10100
• HGNCID: 20659
• Length: 221
• Species: Homo sapiens
• Alignment Length: 234
• Identity: 57/234 - (24%)
• Similarity: 105/234 - (44%)
• Gaps: 55/234 - (23%)

  Fly     8 IKYSLFLFNALWAILGILVLIFGGLGW----GAM---------PDAYAIGILIL---GGTILVIS 56
            |||.|..||.|:.:.|..|:.||  .|    ||:         |:.:.:|:.:|   |..::.:.
Human    11 IKYLLLGFNLLFWLAGSAVIAFG--LWFRFGGAIKELSSEDKSPEYFYVGLYVLVGAGALMMAVG 73

  Fly    57 LFGCCGAVRESPRMLWTYASLLLILLLL-----IVAFIILNPKDVFKKYALQTVENQWE------ 110
            .||||||:|||..:|.::.:.||::...     :.|||       .|..|::.|:..:|
Human    74 FFGCCGAMRESQCVLGSFFTCLLVIFAAEVTTGVFAFI-------GKGVAIRHVQTMYEEAYNDY 131

  Fly   111 LEQTKPGSMDII--QKTYYCCGRDSAQDYLDIKFWNNTVPSSCCKDDSCVNPLNLYVRGCLIKVE 173
            |:....|:..:|  ..|:.|||::|::.          |..:|.|:       .|..:.|:.::|
Human   132 LKDRGKGNGTLITFHSTFQCCGKESSEQ----------VQPTCPKE-------LLGHKNCIDEIE 179

  Fly   174 EAFADEATTLGYLEWGLLGFNAVILLLAIILAIHYTNRR 212
            ...:.:...:|.:..|:.|.....::.:::|.....|.|
Human   180 TIISVKLQLIGIVGIGIAGLTIFGMIFSMVLCCAIRNSR 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42El	NP_523638.1	Tetraspanin	8..>130	CDD:459767	42/150 (28%)
		tetraspanin_LEL	94..178	CDD:239401	18/91 (20%)
TSPAN2	NP_005716.2	Tetraspanin	11..212	CDD:459767	55/226 (24%)
		CD81_like_LEL	110..186	CDD:239404	20/99 (20%)