Protein Alignment Tsp42Ei and TSPAN14

DIOPT Version :10

• Sequence 1: NP_523635.2
• Gene: Tsp42Ei / 35618
• FlyBaseID: FBgn0033130
• Length: 229
• Species: Drosophila melanogaster
• Sequence 2: NP_112189.2
• Gene: TSPAN14 / 81619
• HGNCID: 23303
• Length: 270
• Species: Homo sapiens
• Alignment Length: 248
• Identity: 57/248 - (22%)
• Similarity: 94/248 - (37%)
• Gaps: 67/248 - (27%)

  Fly     9 KHVLLLLNFVFSVLGLALIAFGIFFLISAAENAV-----------SIGKNVAGGLIIALGVVILI 62
            |::|...|.:|.:.|:..:..|::   :.:|..|           .|...|   |::.:|||:..
Human    16 KYLLFSYNIIFWLAGVVFLGVGLW---AWSEKGVLSDLTKVTRMHGIDPVV---LVLMVGVVMFT 74

  Fly    63 IAIFGCLAAIHEAPVRLLIYVGAVVL-----LILAQLIFLGMSSHGTKDGISGSINEGFDRLWES 122
            :...||:.|:.|....|..:.|.:||     |.:|.|.||      .:|.:.....|.|:...:|
Human    75 LGFAGCVGALRENICLLNFFCGTIVLIFFLELAVAVLAFL------FQDWVRDRFREFFESNIKS 133

  Fly   123 ERNQTGALSYYESWL---QCCGVNSSEDYWIIH--------------HGIPSSCC---PESKCMD 167
            .|:.....:..:|..   ||||....|| |.::              .|:|.|||   |..|.::
Human   134 YRDDIDLQNLIDSLQKANQCCGAYGPED-WDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVN 197

  Fly   168 T--------------PSRVFKTGCKAAFVKYLDDKLL----VFKIVCWLLVIG 202
            |              ...:|..||..|...:|...:.    ||..:..|.:.|
Human   198 TQCGYDVRIQLKSKWDESIFTKGCIQALESWLPRNIYIVAGVFIAISLLQIFG 250

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp42Ei	NP_523635.2	Tetraspanin	8..214	CDD:459767	57/248 (23%)
TSPAN14	NP_112189.2	Tetraspanin	16..258	CDD:459767	57/248 (23%)
		TM4SF9_like_LEL	113..233	CDD:239412	28/126 (22%)
		Necessary and sufficient for interaction with ADAM10. /evidence=ECO:0000269|PubMed:26668317	114..232		27/124 (22%)